Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework
Abstract Chirality plays a pivotal role in the properties of biologically active molecules, with enantiomers exhibiting divergent pharmacological and toxicological profiles. Enantioselective recognition is thus crucial in drug development, asymmetric synthesis, and environmental monitoring. Luminesc...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-025-01605-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849237674845536256 |
|---|---|
| author | Zongsu Han Tiankai Sun Peng Cheng Wei Shi |
| author_facet | Zongsu Han Tiankai Sun Peng Cheng Wei Shi |
| author_sort | Zongsu Han |
| collection | DOAJ |
| description | Abstract Chirality plays a pivotal role in the properties of biologically active molecules, with enantiomers exhibiting divergent pharmacological and toxicological profiles. Enantioselective recognition is thus crucial in drug development, asymmetric synthesis, and environmental monitoring. Luminescence sensing has emerged as a powerful strategy for enantioselective recognition due to its fast response and visual readout capabilities. Covalent-organic frameworks (COFs) offer a promising platform for such applications by combining structural robustness, modular functionality, and inherent porosity. However, achieving both high enantioselectivity and quantitative sensing within a single system remains highly challenging. Herein, we present a cation-induced strategy for enantioselective sensing using a terbium-loaded chiral COF, Tb@CD-COF. Through a facile cation exchange of piperazine cations of CD-COF with Tb3+ ions, we revealed a synergistic integration of cation-enhanced luminescence and chiral cavity-based enantioselective recognition mechanism. Tb@CD-COF demonstrates visually discernible colorimetric responses and quantitative enantiomer discrimination, offering a robust and efficient platform for advanced enantioselective sensing applications. |
| format | Article |
| id | doaj-art-2d4cf5f5790946b39b8621eeb783af6d |
| institution | Kabale University |
| issn | 2399-3669 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Chemistry |
| spelling | doaj-art-2d4cf5f5790946b39b8621eeb783af6d2025-08-20T04:01:53ZengNature PortfolioCommunications Chemistry2399-36692025-07-01811710.1038/s42004-025-01605-zCation-induced enhanced enantioselective recognition by a chiral covalent-organic frameworkZongsu Han0Tiankai Sun1Peng Cheng2Wei Shi3Frontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai UniversityFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai UniversityFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai UniversityFrontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Key Laboratory of Advanced Energy Materials Chemistry (MOE), College of Chemistry, Nankai UniversityAbstract Chirality plays a pivotal role in the properties of biologically active molecules, with enantiomers exhibiting divergent pharmacological and toxicological profiles. Enantioselective recognition is thus crucial in drug development, asymmetric synthesis, and environmental monitoring. Luminescence sensing has emerged as a powerful strategy for enantioselective recognition due to its fast response and visual readout capabilities. Covalent-organic frameworks (COFs) offer a promising platform for such applications by combining structural robustness, modular functionality, and inherent porosity. However, achieving both high enantioselectivity and quantitative sensing within a single system remains highly challenging. Herein, we present a cation-induced strategy for enantioselective sensing using a terbium-loaded chiral COF, Tb@CD-COF. Through a facile cation exchange of piperazine cations of CD-COF with Tb3+ ions, we revealed a synergistic integration of cation-enhanced luminescence and chiral cavity-based enantioselective recognition mechanism. Tb@CD-COF demonstrates visually discernible colorimetric responses and quantitative enantiomer discrimination, offering a robust and efficient platform for advanced enantioselective sensing applications.https://doi.org/10.1038/s42004-025-01605-z |
| spellingShingle | Zongsu Han Tiankai Sun Peng Cheng Wei Shi Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework Communications Chemistry |
| title | Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework |
| title_full | Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework |
| title_fullStr | Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework |
| title_full_unstemmed | Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework |
| title_short | Cation-induced enhanced enantioselective recognition by a chiral covalent-organic framework |
| title_sort | cation induced enhanced enantioselective recognition by a chiral covalent organic framework |
| url | https://doi.org/10.1038/s42004-025-01605-z |
| work_keys_str_mv | AT zongsuhan cationinducedenhancedenantioselectiverecognitionbyachiralcovalentorganicframework AT tiankaisun cationinducedenhancedenantioselectiverecognitionbyachiralcovalentorganicframework AT pengcheng cationinducedenhancedenantioselectiverecognitionbyachiralcovalentorganicframework AT weishi cationinducedenhancedenantioselectiverecognitionbyachiralcovalentorganicframework |