Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features
Objective: To utilize radiomics features to enhance the prediction of personalized organ doses from CT scans, in order to explore methods for improving neural network-based models. Methods: Patient CT DICOM files were processed using DeepViewer to define regions of interest (ROIs) in their organs. R...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Radiation Medicine and Protection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666555725000218 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849698441562685440 |
|---|---|
| author | Wencheng Shao Xin Lin Ying Huang Liangyong Qu Weihai Zhuo Haikuan Liu |
| author_facet | Wencheng Shao Xin Lin Ying Huang Liangyong Qu Weihai Zhuo Haikuan Liu |
| author_sort | Wencheng Shao |
| collection | DOAJ |
| description | Objective: To utilize radiomics features to enhance the prediction of personalized organ doses from CT scans, in order to explore methods for improving neural network-based models. Methods: Patient CT DICOM files were processed using DeepViewer to define regions of interest (ROIs) in their organs. Radiomics features were extracted from the CT images and ROIs, and benchmark organ doses were calculated using Monte Carlo simulations. Fully-connected neural networks (FCNN) were trained with radiomics features to predict organ doses. The FCNN model was optimized by adjusting the number of input radiomics features and FCNN layers. Performance was evaluated using relative root mean squared error (RRMSE) and R-squared (R2). Results: Higher RRMSE and lower R2 values are observed when fewer than 30 input radiomics features are used for head CTs and fewer than 10 for chesst CTs. Increasing input features didn't significantly improve FCNN's performance. For head CTs, FCNN's layer quantities affected predictive stability, with better robustness observed with 4- and 5-layer FCNN. Specifically, the median RRMSE was reduced to 8.14% for the brain, 10.27% for the left eye, and 10.16% for the right eye when using 30 or more radiomics features. For chest CTs, the model's predictive stability was less sensitive to the number of layers, with median RRMSE values of 9.58% for the left lung and 9.44% for the right lung, and R² values of 0.76 for both lungs. Conclusions: Optimizing feature quantities and neural network layers enhances performance in predicting organ doses from CT scans. Specifically, head CTs show optimal results with 4–5 layers, while chest CTs do not significantly benefit from increased layers. |
| format | Article |
| id | doaj-art-2d4cb3997eb8405a8b9545d3da75e393 |
| institution | DOAJ |
| issn | 2666-5557 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiation Medicine and Protection |
| spelling | doaj-art-2d4cb3997eb8405a8b9545d3da75e3932025-08-20T03:18:54ZengElsevierRadiation Medicine and Protection2666-55572025-04-0162819010.1016/j.radmp.2025.02.002Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics featuresWencheng Shao0Xin Lin1Ying Huang2Liangyong Qu3Weihai Zhuo4Haikuan Liu5Institute of Radiation Medicine, Fudan University, Shanghai 200032, ChinaInstitute of Radiation Medicine, Fudan University, Shanghai 200032, ChinaDepartment of Nuclear Science and Technology, Institute of Modern Physics, Fudan University, Shanghai 200433, ChinaDepartment of Radiology, Shanghai Zhongye Hospital, Shanghai 201900, ChinaInstitute of Radiation Medicine, Fudan University, Shanghai 200032, China; Corresponding author.Institute of Radiation Medicine, Fudan University, Shanghai 200032, China; Corresponding author.Objective: To utilize radiomics features to enhance the prediction of personalized organ doses from CT scans, in order to explore methods for improving neural network-based models. Methods: Patient CT DICOM files were processed using DeepViewer to define regions of interest (ROIs) in their organs. Radiomics features were extracted from the CT images and ROIs, and benchmark organ doses were calculated using Monte Carlo simulations. Fully-connected neural networks (FCNN) were trained with radiomics features to predict organ doses. The FCNN model was optimized by adjusting the number of input radiomics features and FCNN layers. Performance was evaluated using relative root mean squared error (RRMSE) and R-squared (R2). Results: Higher RRMSE and lower R2 values are observed when fewer than 30 input radiomics features are used for head CTs and fewer than 10 for chesst CTs. Increasing input features didn't significantly improve FCNN's performance. For head CTs, FCNN's layer quantities affected predictive stability, with better robustness observed with 4- and 5-layer FCNN. Specifically, the median RRMSE was reduced to 8.14% for the brain, 10.27% for the left eye, and 10.16% for the right eye when using 30 or more radiomics features. For chest CTs, the model's predictive stability was less sensitive to the number of layers, with median RRMSE values of 9.58% for the left lung and 9.44% for the right lung, and R² values of 0.76 for both lungs. Conclusions: Optimizing feature quantities and neural network layers enhances performance in predicting organ doses from CT scans. Specifically, head CTs show optimal results with 4–5 layers, while chest CTs do not significantly benefit from increased layers.http://www.sciencedirect.com/science/article/pii/S2666555725000218CTPersonalized organ doseRadiomics featuresNeural networkOptimization |
| spellingShingle | Wencheng Shao Xin Lin Ying Huang Liangyong Qu Weihai Zhuo Haikuan Liu Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features Radiation Medicine and Protection CT Personalized organ dose Radiomics features Neural network Optimization |
| title | Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features |
| title_full | Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features |
| title_fullStr | Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features |
| title_full_unstemmed | Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features |
| title_short | Swift prediction of personalized head and chest organ doses from CT examinations via neural networks with optimized quantity of hidden layers and radiomics features |
| title_sort | swift prediction of personalized head and chest organ doses from ct examinations via neural networks with optimized quantity of hidden layers and radiomics features |
| topic | CT Personalized organ dose Radiomics features Neural network Optimization |
| url | http://www.sciencedirect.com/science/article/pii/S2666555725000218 |
| work_keys_str_mv | AT wenchengshao swiftpredictionofpersonalizedheadandchestorgandosesfromctexaminationsvianeuralnetworkswithoptimizedquantityofhiddenlayersandradiomicsfeatures AT xinlin swiftpredictionofpersonalizedheadandchestorgandosesfromctexaminationsvianeuralnetworkswithoptimizedquantityofhiddenlayersandradiomicsfeatures AT yinghuang swiftpredictionofpersonalizedheadandchestorgandosesfromctexaminationsvianeuralnetworkswithoptimizedquantityofhiddenlayersandradiomicsfeatures AT liangyongqu swiftpredictionofpersonalizedheadandchestorgandosesfromctexaminationsvianeuralnetworkswithoptimizedquantityofhiddenlayersandradiomicsfeatures AT weihaizhuo swiftpredictionofpersonalizedheadandchestorgandosesfromctexaminationsvianeuralnetworkswithoptimizedquantityofhiddenlayersandradiomicsfeatures AT haikuanliu swiftpredictionofpersonalizedheadandchestorgandosesfromctexaminationsvianeuralnetworkswithoptimizedquantityofhiddenlayersandradiomicsfeatures |