Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer
Background: Hinokitiol (β-thujaplicin), a naturally occurring tropolone derivative, exhibits multifaceted pharmacological properties. The aim of this review is to explore the medicinal potential of hinokitiol in different biological systems. Objectives: To systematically investigate hinokitiol'...
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Elsevier
2024-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142524001696 |
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| author | Karthik K Karunakar Binoy Varghese Cheriyan Ramaiyan Velmurugan Meenaloshini Gopalakrishnan Karthikha VS |
| author_facet | Karthik K Karunakar Binoy Varghese Cheriyan Ramaiyan Velmurugan Meenaloshini Gopalakrishnan Karthikha VS |
| author_sort | Karthik K Karunakar |
| collection | DOAJ |
| description | Background: Hinokitiol (β-thujaplicin), a naturally occurring tropolone derivative, exhibits multifaceted pharmacological properties. The aim of this review is to explore the medicinal potential of hinokitiol in different biological systems. Objectives: To systematically investigate hinokitiol's anti-inflammatory, antimicrobial, and antineoplastic properties; explore its molecular mechanisms of action; determine its toxicological profile; and future research. Methods: We conducted a search on PubMed, Scopus, and Web of Science for research publications. Initially, we recognized 300 studies. Following a comprehensive analysis, 186 studies reported the pharmacological properties of hinokitiol. We excluded articles that either lacked experimental rigor or provided insufficient mechanistic insight. Results: Hinokitiol demonstrates significant anti-inflammatory effects through modulation of NF-κB, MAPK, and associated signaling cascades. Its broad-spectrum antimicrobial activity has bactericidal, fungicidal, and antiviral properties, with unique mechanisms of action that may circumvent conventional resistance pathways. Anticancer effects have been observed in multiple neoplastic cell lines and animal models, including breast, lung, endometrial, and hepatocellular carcinomas, mediated through induction of apoptosis, cell cycle arrest, and modulation of autophagic processes. Additional studies indicate antioxidant, neuroprotective, and dermatological benefits. Toxicological assessments suggest favorable tolerability at therapeutic doses, though comprehensive human safety data remain limited. Conclusions: Hinokitiol shows significant potential for treating infections, inflammation, and cancers by targeting key cellular pathways. However, further research is needed to optimize its dosage, ensure safety, and improve bioavailability for clinical use. While promising, more studies are required to translate its preclinical success into effective therapies. |
| format | Article |
| id | doaj-art-2d4a9f20f6d44ad59d67c27e4c49e1b9 |
| institution | OA Journals |
| issn | 2667-1425 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj-art-2d4a9f20f6d44ad59d67c27e4c49e1b92025-08-20T02:34:53ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252024-12-011310052710.1016/j.prmcm.2024.100527Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and CancerKarthik K Karunakar0Binoy Varghese Cheriyan1Ramaiyan Velmurugan2Meenaloshini Gopalakrishnan3Karthikha VS4Department of Pharmacy Practice, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, IndiaDepartment of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, India; Corresponding author.Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, IndiaDepartment of Pharmacy Practice, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, IndiaDepartment of Pharmacy Practice, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, IndiaBackground: Hinokitiol (β-thujaplicin), a naturally occurring tropolone derivative, exhibits multifaceted pharmacological properties. The aim of this review is to explore the medicinal potential of hinokitiol in different biological systems. Objectives: To systematically investigate hinokitiol's anti-inflammatory, antimicrobial, and antineoplastic properties; explore its molecular mechanisms of action; determine its toxicological profile; and future research. Methods: We conducted a search on PubMed, Scopus, and Web of Science for research publications. Initially, we recognized 300 studies. Following a comprehensive analysis, 186 studies reported the pharmacological properties of hinokitiol. We excluded articles that either lacked experimental rigor or provided insufficient mechanistic insight. Results: Hinokitiol demonstrates significant anti-inflammatory effects through modulation of NF-κB, MAPK, and associated signaling cascades. Its broad-spectrum antimicrobial activity has bactericidal, fungicidal, and antiviral properties, with unique mechanisms of action that may circumvent conventional resistance pathways. Anticancer effects have been observed in multiple neoplastic cell lines and animal models, including breast, lung, endometrial, and hepatocellular carcinomas, mediated through induction of apoptosis, cell cycle arrest, and modulation of autophagic processes. Additional studies indicate antioxidant, neuroprotective, and dermatological benefits. Toxicological assessments suggest favorable tolerability at therapeutic doses, though comprehensive human safety data remain limited. Conclusions: Hinokitiol shows significant potential for treating infections, inflammation, and cancers by targeting key cellular pathways. However, further research is needed to optimize its dosage, ensure safety, and improve bioavailability for clinical use. While promising, more studies are required to translate its preclinical success into effective therapies.http://www.sciencedirect.com/science/article/pii/S2667142524001696HinokitiolAnti-inflammatoryAnticancerBiological expressionsCell regulation |
| spellingShingle | Karthik K Karunakar Binoy Varghese Cheriyan Ramaiyan Velmurugan Meenaloshini Gopalakrishnan Karthikha VS Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer Pharmacological Research - Modern Chinese Medicine Hinokitiol Anti-inflammatory Anticancer Biological expressions Cell regulation |
| title | Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer |
| title_full | Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer |
| title_fullStr | Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer |
| title_full_unstemmed | Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer |
| title_short | Mechanistic insights and therapeutic applications of Hinokitiol in Inflammation, Antimicrobial therapy, and Cancer |
| title_sort | mechanistic insights and therapeutic applications of hinokitiol in inflammation antimicrobial therapy and cancer |
| topic | Hinokitiol Anti-inflammatory Anticancer Biological expressions Cell regulation |
| url | http://www.sciencedirect.com/science/article/pii/S2667142524001696 |
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