The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma
This review delves into the pivotal role and intricate mechanisms of aerobic glycolysis in nasopharyngeal carcinoma (NPC). NPC, a malignancy originating from the nasopharyngeal epithelium, displays distinct geographical and clinical features. The article emphasizes the significance of aerobic glycol...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2025-04-01
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| Online Access: | https://peerj.com/articles/19213.pdf |
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| author | Zhiyong Pan Yuyi Liu Hui Li Huisi Qiu Pingmei Zhang Zhiying Li Xinyu Wang Yuxiao Tian Zhengfu Feng Song Zhu Xin Wang |
| author_facet | Zhiyong Pan Yuyi Liu Hui Li Huisi Qiu Pingmei Zhang Zhiying Li Xinyu Wang Yuxiao Tian Zhengfu Feng Song Zhu Xin Wang |
| author_sort | Zhiyong Pan |
| collection | DOAJ |
| description | This review delves into the pivotal role and intricate mechanisms of aerobic glycolysis in nasopharyngeal carcinoma (NPC). NPC, a malignancy originating from the nasopharyngeal epithelium, displays distinct geographical and clinical features. The article emphasizes the significance of aerobic glycolysis, a pivotal metabolic alteration in cancer cells, in NPC progression. Key enzymes such as hexokinase 2, lactate dehydrogenase A, phosphofructokinase 1, and pyruvate kinase M2 are discussed for their regulatory functions in NPC glycolysis through signaling pathways like PI3K/Akt and mTOR. Further, the article explores how oncogenic signaling pathways and transcription factors like c-Myc and HIF-1α modulate aerobic glycolysis, thereby affecting NPC’s proliferation, invasion, metastasis, angiogenesis, and immune evasion. By elucidating these mechanisms, the review aims to advance research and clinical practice in NPC, informing the development of targeted therapeutic strategies that enhance treatment precision and reduce side effects. Overall, this review offers a broad understanding of the multifaceted role of aerobic glycolysis in NPC and its potential impact on therapeutic outcomes. |
| format | Article |
| id | doaj-art-2d47ee6db39d46718ff9f1fbb07ed07f |
| institution | OA Journals |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-2d47ee6db39d46718ff9f1fbb07ed07f2025-08-20T01:52:22ZengPeerJ Inc.PeerJ2167-83592025-04-0113e1921310.7717/peerj.19213The role and mechanism of aerobic glycolysis in nasopharyngeal carcinomaZhiyong Pan0Yuyi Liu1Hui Li2Huisi Qiu3Pingmei Zhang4Zhiying Li5Xinyu Wang6Yuxiao Tian7Zhengfu Feng8Song Zhu9Xin Wang10Department of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Ophthalmology, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaDepartment of Radiotherapy, Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, Guangdong, ChinaThis review delves into the pivotal role and intricate mechanisms of aerobic glycolysis in nasopharyngeal carcinoma (NPC). NPC, a malignancy originating from the nasopharyngeal epithelium, displays distinct geographical and clinical features. The article emphasizes the significance of aerobic glycolysis, a pivotal metabolic alteration in cancer cells, in NPC progression. Key enzymes such as hexokinase 2, lactate dehydrogenase A, phosphofructokinase 1, and pyruvate kinase M2 are discussed for their regulatory functions in NPC glycolysis through signaling pathways like PI3K/Akt and mTOR. Further, the article explores how oncogenic signaling pathways and transcription factors like c-Myc and HIF-1α modulate aerobic glycolysis, thereby affecting NPC’s proliferation, invasion, metastasis, angiogenesis, and immune evasion. By elucidating these mechanisms, the review aims to advance research and clinical practice in NPC, informing the development of targeted therapeutic strategies that enhance treatment precision and reduce side effects. Overall, this review offers a broad understanding of the multifaceted role of aerobic glycolysis in NPC and its potential impact on therapeutic outcomes.https://peerj.com/articles/19213.pdfAerobic glycolysisNasopharyngeal carcinomaKey enzymesTranscription factorsSignaling pathways |
| spellingShingle | Zhiyong Pan Yuyi Liu Hui Li Huisi Qiu Pingmei Zhang Zhiying Li Xinyu Wang Yuxiao Tian Zhengfu Feng Song Zhu Xin Wang The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma PeerJ Aerobic glycolysis Nasopharyngeal carcinoma Key enzymes Transcription factors Signaling pathways |
| title | The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma |
| title_full | The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma |
| title_fullStr | The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma |
| title_full_unstemmed | The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma |
| title_short | The role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma |
| title_sort | role and mechanism of aerobic glycolysis in nasopharyngeal carcinoma |
| topic | Aerobic glycolysis Nasopharyngeal carcinoma Key enzymes Transcription factors Signaling pathways |
| url | https://peerj.com/articles/19213.pdf |
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