Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis
Sleep deprivation is a common public problem, and researchers speculated its neurophysiological mechanisms related to cortical excitatory and inhibitory activity. Recently, transcranial magnetic stimulation combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) have been used...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000024 |
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| author | Yihui Zhang Yuan Shi Ye Zhang Jian Jiao Xiangdong Tang |
| author_facet | Yihui Zhang Yuan Shi Ye Zhang Jian Jiao Xiangdong Tang |
| author_sort | Yihui Zhang |
| collection | DOAJ |
| description | Sleep deprivation is a common public problem, and researchers speculated its neurophysiological mechanisms related to cortical excitatory and inhibitory activity. Recently, transcranial magnetic stimulation combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) have been used to assess cortical excitability in sleep-deprived individuals, but the results were inconsistent. Therefore, we conducted a meta-analysis to summarize relevant TMS-evoked indices of excitability and inhibition for exploring the cortical effects of sleep deprivation. In TMS-EMG studies, short-interval cortical inhibition (SICI) significantly decreased in sleep-deprived subjects; while the intracortical facilitation (ICF), resting motor threshold (RMT), and cortical silent period (CSP) were not significant compared to healthy controls. In TMS-EEG studies, the amplitude and slope of TMS-evoked potential (TEP) increased in sleep-deprived subjects. This study indicated that cortical inhibition decreased following sleep deprivation based on the TMS-EMG results and cortical excitability enhanced in the TMS-EEG results, supporting the disturbance of cortical excitability in sleep-deprived individuals. |
| format | Article |
| id | doaj-art-2d45404fd3554334af9a1f3ee39a4fbb |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-2d45404fd3554334af9a1f3ee39a4fbb2025-02-07T04:46:40ZengElsevierBrain Research Bulletin1873-27472025-02-01221111190Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysisYihui Zhang0Yuan Shi1Ye Zhang2Jian Jiao3Xiangdong Tang4Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaSleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaSleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaSleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaCorrespondence to: Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, China.; Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaSleep deprivation is a common public problem, and researchers speculated its neurophysiological mechanisms related to cortical excitatory and inhibitory activity. Recently, transcranial magnetic stimulation combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) have been used to assess cortical excitability in sleep-deprived individuals, but the results were inconsistent. Therefore, we conducted a meta-analysis to summarize relevant TMS-evoked indices of excitability and inhibition for exploring the cortical effects of sleep deprivation. In TMS-EMG studies, short-interval cortical inhibition (SICI) significantly decreased in sleep-deprived subjects; while the intracortical facilitation (ICF), resting motor threshold (RMT), and cortical silent period (CSP) were not significant compared to healthy controls. In TMS-EEG studies, the amplitude and slope of TMS-evoked potential (TEP) increased in sleep-deprived subjects. This study indicated that cortical inhibition decreased following sleep deprivation based on the TMS-EMG results and cortical excitability enhanced in the TMS-EEG results, supporting the disturbance of cortical excitability in sleep-deprived individuals.http://www.sciencedirect.com/science/article/pii/S0361923025000024Cortical excitabilityCortical inhibitionSleep deprivationTMSSICIICF |
| spellingShingle | Yihui Zhang Yuan Shi Ye Zhang Jian Jiao Xiangdong Tang Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis Brain Research Bulletin Cortical excitability Cortical inhibition Sleep deprivation TMS SICI ICF |
| title | Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis |
| title_full | Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis |
| title_fullStr | Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis |
| title_full_unstemmed | Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis |
| title_short | Cortical excitability on sleep deprivation measured by transcranial magnetic stimulation: A systematic review and meta-analysis |
| title_sort | cortical excitability on sleep deprivation measured by transcranial magnetic stimulation a systematic review and meta analysis |
| topic | Cortical excitability Cortical inhibition Sleep deprivation TMS SICI ICF |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000024 |
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