Immune training enhances anti-viral responses and improves outcomes in Pax5 −/+ mice susceptible to chronic infection

Immune training enhances anti-viral responses and improves outcomes in Pax5 −/+ mice susceptible to chronic infection

Abstract Viral infections pose a significant global burden. Host susceptibility to pathogens is determined by many factors including genetic variation that can lead to immunodeficient or dysregulated antiviral immune responses. Pax5 heterozygosity (Pax5 −/+), resulting in reduced PAX5 levels in mice...

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Main Authors: Zhe Lu, Olivia Stencel, Wei Liu, Eleni Vasileiou, Haifeng C Xu, Piyush Pandey, Paweł Stachura, Abdelrahman Elwy, Anastassia Tsombal, Ann-Sophie Mai, Franziska Auer, Mina N F Morcos, Maximilian Seidl, Sarah Koziel, Peter-Martin Bruch, Sascha Dietrich, Sarah Elitzur, Gunther Hartmann, Karl S Lang, Stefan Janssen, Ute Fischer, Sanil Bhatia, Philipp A Lang, Arndt Borkhardt, Julia Hauer, Aleksandra A Pandyra
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
Subjects:
Trained Immunity
Chronic Infection
LCMV
PAX5
β-glucan
Online Access:https://doi.org/10.1038/s44321-025-00208-4
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