SYNTHESIS OF NEW N-HYDROXYPHENYL AND TOLYL DERIVATIVES OF PYRIMIDINE-4(1H) –ONE WITH ANTI-INFLAMMATORY ACTIVITY

SYNTHESIS OF NEW N-HYDROXYPHENYL AND TOLYL DERIVATIVES OF PYRIMIDINE-4(1H) –ONE WITH ANTI-INFLAMMATORY ACTIVITY

In their structure pyrimidin-4-one derivatives are similar to the endogenous nitrogen bases. This makes it possible to predict a wide range of pharmacological activities characteristic for them. The compounds of this series exhibit neurotropic, immunotropic, actoprotective, hypotensive, antihypoxic,...

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Bibliographic Details
Main Authors: I. P. Kodonidi, O. O. Novikov, S. A. Kuleshova, Ju. I. Rjabukhin, S. S. Shatokhin, A. V. Ivchenko, M. I. Kodonidi, O. M. Zhilina
Format: Article
Language:Russian
Published: Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute 2018-01-01
Series:Фармация и фармакология (Пятигорск)
Subjects:
pyrimidin-4(1h)-one, molecular construction, targeted synthesis, cyclocondensation, cyclooxygenase, anti-infl ammatory action, antiexudative activity
Online Access:https://www.pharmpharm.ru/jour/article/view/279
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