Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model

Prenatal modulation of NADPH-oxidase reverses the deranged GABA switch and rescues behavioral deficits in valproate ASD rat model

IndroductionImpaired depolarizing-to-hyperpolarizing (D/H) switch of gamma-aminobutyric acid (GABA) is reported during brain development in rodent valproate-model of autism spectrum disorder (VPA-ASD). We hypothesize that this impairment triggers NADPH oxidases (NOXs)-induced reactive oxygen species...

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Main Authors: Basma A. Yasseen, Hadeer Abdelkhalek, Sara Gohar, Yasmin Hatem, Hajar El-Sayed, Aya A. Elkhodiry, Aya Galal, Aya Samir, Nouran Al-Shehaby, Malak W. Elbenhawi, Rehab Hamdy, Christine S. Prince, Azza G. Kamel, Mohamed A. Badawy, Ghada F. Soliman, Soha Aly ElMorsy, Tamer M. Gamal El-Din, Ebtehal El-Demerdash, Sameh S. Ali, Engy A. Abdel-Rahman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
ASD
GABA D/H switch
synaptosomes
KCC2
NOX
shikonin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1571008/full
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