Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy
In the last decades, major changes in ecosystems related to industrial development and environmental modifications have had a direct impact on mammalian fertility, as well as on biodiversity. It is widely demonstrated that all these changes impair reproductive function. Several studies have connecte...
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MDPI AG
2025-01-01
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| Series: | Animals |
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| author | Filipa C. Ferreira José Teixeira Fernando Lidon Fernando Cagide Fernanda Borges Rosa M. L. N. Pereira |
| author_facet | Filipa C. Ferreira José Teixeira Fernando Lidon Fernando Cagide Fernanda Borges Rosa M. L. N. Pereira |
| author_sort | Filipa C. Ferreira |
| collection | DOAJ |
| description | In the last decades, major changes in ecosystems related to industrial development and environmental modifications have had a direct impact on mammalian fertility, as well as on biodiversity. It is widely demonstrated that all these changes impair reproductive function. Several studies have connected the increase of reactive oxygen species (ROS) generated in mitochondria to the recently identified decline of fertility due to various factors, including heat stress. The study of antioxidants, and especially of mitochondria targeted antioxidants, has been focused on identifying more efficient and less toxic therapies that could circumvent fertility problems. These antioxidants can be derived from natural compounds in the diet and delivered to the mitochondria in more effective forms, providing a much more natural therapy. The use of mitochondriotropic diet-based antioxidants in assisted reproductive technologies (ART) may be an important way to overcome low fertility, allowing the conservation of animal biodiversity and productivity. This paper provides a concise review of the current state of the art on this topic, with a particular focus on the antioxidants mitoquinone, AntiOxBEN<sub>2</sub>, AntiOxCIN<sub>4</sub>, urolithin A and piperine, and their effects on bovine and other animal species. |
| format | Article |
| id | doaj-art-2d3f80fea4004c1eb8cb2bbd299c16cf |
| institution | OA Journals |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-2d3f80fea4004c1eb8cb2bbd299c16cf2025-08-20T02:12:37ZengMDPI AGAnimals2076-26152025-01-0115328910.3390/ani15030289Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant TherapyFilipa C. Ferreira0José Teixeira1Fernando Lidon2Fernando Cagide3Fernanda Borges4Rosa M. L. N. Pereira5Unit of Biotechnology and Genetic Resources, National Institute of Agrarian and Veterinary Research, Quinta da Fonte Boa, 2005-424 Vale de Santarém, PortugalCNC—Centre for Neurosciences and Cell Biology, University of Coimbra, 3004-504 Coimbra, PortugalGeoBioTec—Faculty of Sciences and Technology, New University of Lisbon, Campus da Caparica, 2829-516 Caparica, PortugalCIQ-Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Campo Alegre, 4169-007 Porto, PortugalCIQ-Department of Chemistry and Biochemistry, Faculty of Science, University of Porto, Campo Alegre, 4169-007 Porto, PortugalUnit of Biotechnology and Genetic Resources, National Institute of Agrarian and Veterinary Research, Quinta da Fonte Boa, 2005-424 Vale de Santarém, PortugalIn the last decades, major changes in ecosystems related to industrial development and environmental modifications have had a direct impact on mammalian fertility, as well as on biodiversity. It is widely demonstrated that all these changes impair reproductive function. Several studies have connected the increase of reactive oxygen species (ROS) generated in mitochondria to the recently identified decline of fertility due to various factors, including heat stress. The study of antioxidants, and especially of mitochondria targeted antioxidants, has been focused on identifying more efficient and less toxic therapies that could circumvent fertility problems. These antioxidants can be derived from natural compounds in the diet and delivered to the mitochondria in more effective forms, providing a much more natural therapy. The use of mitochondriotropic diet-based antioxidants in assisted reproductive technologies (ART) may be an important way to overcome low fertility, allowing the conservation of animal biodiversity and productivity. This paper provides a concise review of the current state of the art on this topic, with a particular focus on the antioxidants mitoquinone, AntiOxBEN<sub>2</sub>, AntiOxCIN<sub>4</sub>, urolithin A and piperine, and their effects on bovine and other animal species.https://www.mdpi.com/2076-2615/15/3/289fertilityreproductiongameteembryosoxidative stressantioxidants |
| spellingShingle | Filipa C. Ferreira José Teixeira Fernando Lidon Fernando Cagide Fernanda Borges Rosa M. L. N. Pereira Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy Animals fertility reproduction gamete embryos oxidative stress antioxidants |
| title | Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy |
| title_full | Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy |
| title_fullStr | Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy |
| title_full_unstemmed | Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy |
| title_short | Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy |
| title_sort | assisted reproduction technologies art impact of mitochondrial dys function and antioxidant therapy |
| topic | fertility reproduction gamete embryos oxidative stress antioxidants |
| url | https://www.mdpi.com/2076-2615/15/3/289 |
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