Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells

Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells

Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities. In this study, apigenin, luteolin, and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone induced insulin-resistant (IR) HepG2 cells. All fla...

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Main Authors: Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao
Format: Article
Language:English
Published: Tsinghua University Press 2023-11-01
Series:Food Science and Human Wellness
Subjects:
Apigenin
Luteolin
Baicalein
Insulin-resistant HepG2 cells
Signaling pathway
reactive oxygen species (ROS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213453023000733
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