Goondicones A–H: Spiro-Isoindolinone Heartworm Anthelmintics from an Australian Pasture-Soil-Derived <i>Streptomyces</i> sp.

Goondicones A–H: Spiro-Isoindolinone Heartworm Anthelmintics from an Australian Pasture-Soil-Derived <i>Streptomyces</i> sp.

Background/Objectives: There is an urgent need for new and improved anthelmintics that are not constrained by existing resistance pathways and that can safeguard the health and welfare of animals. Methods: An integrated platform of chemical, bioassay, and cultivation profiling applied to a library o...

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Bibliographic Details
Main Authors:	Jianying Han, David F. Bruhn, Cynthia T. Childs, Yovany Moreno, Angela A. Salim, Taizong Wu, Robert J. Capon
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Antibiotics
Subjects:	anthelmintic citizen science <i>Dirofilaria immitis</i> microbial natural product spiro-isoindolinone Soils for Science
Online Access:	https://www.mdpi.com/2079-6382/13/12/1222
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