Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior
Adult-generated neurons in the dentate gyrus (DG) of the hippocampus play a role in various forms of learning and memory. However, adult born neurons in the DG, while still at an immature stage, exhibit unique electrophysiological properties and are also functionally implicated in learning and memor...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/283829 |
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| _version_ | 1849306534013566976 |
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| author | Megan P. Hicks Kelly C. Wischerath Amber L. Lacrosse M. Foster Olive |
| author_facet | Megan P. Hicks Kelly C. Wischerath Amber L. Lacrosse M. Foster Olive |
| author_sort | Megan P. Hicks |
| collection | DOAJ |
| description | Adult-generated neurons in the dentate gyrus (DG) of the hippocampus play a role in various forms of learning and memory. However, adult born neurons in the DG, while still at an immature stage, exhibit unique electrophysiological properties and are also functionally implicated in learning and memory processes. We investigated the effects of extinction of drug-seeking behavior on the formation of immature neurons in the DG as assessed by quantification of doublecortin (DCX) immunoreactivity. Rats were allowed to self-administer heroin (0.03 mg/kg/infusion) for 12 days and then subjected either to 10 days of extinction training or forced abstinence. We also examined extinction responding patterns following heroin self-administration in glial fibrillary acidic protein thymidine kinase (GFAP-tk) transgenic mice, which have been previously demonstrated to show reduced formation of immature and mature neurons in the DG following treatment with ganciclovir (GCV). We found that extinction training increased DCX immunoreactivity in the dorsal DG as compared with animals undergoing forced abstinence, and that GCV-treated GFAP-tk mice displayed impaired extinction learning as compared to saline-treated mice. Our results suggest that extinction of drug-seeking behavior increases the formation of immature neurons in the DG and that these neurons may play a functional role in extinction learning. |
| format | Article |
| id | doaj-art-2d398fa3184a4fc2bbe81c41325ddfbb |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2d398fa3184a4fc2bbe81c41325ddfbb2025-08-20T03:55:02ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/283829283829Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking BehaviorMegan P. Hicks0Kelly C. Wischerath1Amber L. Lacrosse2M. Foster Olive3Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Psychology, Arizona State University, 950 S. McAllister Avenue, P.O. Box 871104, Tempe, AZ 85287, USADepartment of Psychology, Arizona State University, 950 S. McAllister Avenue, P.O. Box 871104, Tempe, AZ 85287, USADepartment of Psychology, Arizona State University, 950 S. McAllister Avenue, P.O. Box 871104, Tempe, AZ 85287, USAAdult-generated neurons in the dentate gyrus (DG) of the hippocampus play a role in various forms of learning and memory. However, adult born neurons in the DG, while still at an immature stage, exhibit unique electrophysiological properties and are also functionally implicated in learning and memory processes. We investigated the effects of extinction of drug-seeking behavior on the formation of immature neurons in the DG as assessed by quantification of doublecortin (DCX) immunoreactivity. Rats were allowed to self-administer heroin (0.03 mg/kg/infusion) for 12 days and then subjected either to 10 days of extinction training or forced abstinence. We also examined extinction responding patterns following heroin self-administration in glial fibrillary acidic protein thymidine kinase (GFAP-tk) transgenic mice, which have been previously demonstrated to show reduced formation of immature and mature neurons in the DG following treatment with ganciclovir (GCV). We found that extinction training increased DCX immunoreactivity in the dorsal DG as compared with animals undergoing forced abstinence, and that GCV-treated GFAP-tk mice displayed impaired extinction learning as compared to saline-treated mice. Our results suggest that extinction of drug-seeking behavior increases the formation of immature neurons in the DG and that these neurons may play a functional role in extinction learning.http://dx.doi.org/10.1155/2012/283829 |
| spellingShingle | Megan P. Hicks Kelly C. Wischerath Amber L. Lacrosse M. Foster Olive Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior Neural Plasticity |
| title | Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior |
| title_full | Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior |
| title_fullStr | Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior |
| title_full_unstemmed | Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior |
| title_short | Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior |
| title_sort | increases in doublecortin immunoreactivity in the dentate gyrus following extinction of heroin seeking behavior |
| url | http://dx.doi.org/10.1155/2012/283829 |
| work_keys_str_mv | AT meganphicks increasesindoublecortinimmunoreactivityinthedentategyrusfollowingextinctionofheroinseekingbehavior AT kellycwischerath increasesindoublecortinimmunoreactivityinthedentategyrusfollowingextinctionofheroinseekingbehavior AT amberllacrosse increasesindoublecortinimmunoreactivityinthedentategyrusfollowingextinctionofheroinseekingbehavior AT mfosterolive increasesindoublecortinimmunoreactivityinthedentategyrusfollowingextinctionofheroinseekingbehavior |