Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies
ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, foc...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70063 |
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| _version_ | 1849771160173019136 |
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| author | Ki Hoon Kim You‐Ri Kang Jae‐Won Hyun Su‐Hyun Kim Ho Jin Kim |
| author_facet | Ki Hoon Kim You‐Ri Kang Jae‐Won Hyun Su‐Hyun Kim Ho Jin Kim |
| author_sort | Ki Hoon Kim |
| collection | DOAJ |
| description | ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median relapse‐free period of over 5 years. Notably, all patients remained relapse‐free for a median of 36.5 months following discontinuation. Our findings suggest that immunotherapy discontinuation can be a feasible therapeutic strategy for selected patients who have maintained a prolonged relapse‐free period. |
| format | Article |
| id | doaj-art-2d39178480ee461ebe784d0523a6ae06 |
| institution | DOAJ |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-2d39178480ee461ebe784d0523a6ae062025-08-20T03:02:44ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-08-011281689169210.1002/acn3.70063Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG AntibodiesKi Hoon Kim0You‐Ri Kang1Jae‐Won Hyun2Su‐Hyun Kim3Ho Jin Kim4Department of Neurology Severance Hospital, Yonsei University College of Medicine Seoul KoreaDepartment of Neurology Research Institute and Hospital of National Cancer Center Goyang KoreaDepartment of Neurology Research Institute and Hospital of National Cancer Center Goyang KoreaDepartment of Neurology Research Institute and Hospital of National Cancer Center Goyang KoreaDepartment of Neurology Research Institute and Hospital of National Cancer Center Goyang KoreaABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median relapse‐free period of over 5 years. Notably, all patients remained relapse‐free for a median of 36.5 months following discontinuation. Our findings suggest that immunotherapy discontinuation can be a feasible therapeutic strategy for selected patients who have maintained a prolonged relapse‐free period.https://doi.org/10.1002/acn3.70063discontinuationimmunotherapymyelitis |
| spellingShingle | Ki Hoon Kim You‐Ri Kang Jae‐Won Hyun Su‐Hyun Kim Ho Jin Kim Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies Annals of Clinical and Translational Neurology discontinuation immunotherapy myelitis |
| title | Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies |
| title_full | Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies |
| title_fullStr | Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies |
| title_full_unstemmed | Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies |
| title_short | Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies |
| title_sort | discontinuation of immunotherapy in patients with relapsing myelitis without aqp4 mog antibodies |
| topic | discontinuation immunotherapy myelitis |
| url | https://doi.org/10.1002/acn3.70063 |
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