Sphincter of Oddi Function and Dysfunction
The sphincter of Oddi (SO) is situated at the junction of the bile and pancreatic ducts where they enter the duodenum, and it serves to regulate the flow of bile and pancreatic juices as well as to prevent the reflux of duodenal contents into the pancreatobiliary system. SO dysfunction relates to ei...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/313601 |
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| author | James Toouli Alexander Craig |
| author_facet | James Toouli Alexander Craig |
| author_sort | James Toouli |
| collection | DOAJ |
| description | The sphincter of Oddi (SO) is situated at the junction of the bile and pancreatic ducts where they enter the duodenum, and it serves to regulate the flow of bile and pancreatic juices as well as to prevent the reflux of duodenal contents into the pancreatobiliary system. SO dysfunction relates to either the biliary or pancreatic portions of the sphincter. Distinct clinical syndromes relating to either sphincter segment are recognized. The mechanism of dysfunction remains uncertain, but disruption of neural pathways involved in sphincter function seems likely. SO dysfunction is best diagnosed by manometry, which is able to correctly stratify patient groups and determine therapy. Biliary scintigraphy, which is noninvasive, has shown promise as a screening tool for patients with suspected SO dysfunction. Division of the sphincter is an effective treatment for patients with manometrically proven SO stenosis for either the biliary or pancreatic form of the disorder. Other forms of SO dysfunction may benefit from pharmacotherapy. |
| format | Article |
| id | doaj-art-2d373c7f93f04b54b098384558329982 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-2d373c7f93f04b54b0983845583299822025-02-03T01:09:10ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114541141910.1155/2000/313601Sphincter of Oddi Function and DysfunctionJames Toouli0Alexander Craig1Gastrointestinal Surgical Unit, Department of Surgery, Flinders Medical Centre, Adelaide, South Australia, AustraliaGastrointestinal Surgical Unit, Department of Surgery, Flinders Medical Centre, Adelaide, South Australia, AustraliaThe sphincter of Oddi (SO) is situated at the junction of the bile and pancreatic ducts where they enter the duodenum, and it serves to regulate the flow of bile and pancreatic juices as well as to prevent the reflux of duodenal contents into the pancreatobiliary system. SO dysfunction relates to either the biliary or pancreatic portions of the sphincter. Distinct clinical syndromes relating to either sphincter segment are recognized. The mechanism of dysfunction remains uncertain, but disruption of neural pathways involved in sphincter function seems likely. SO dysfunction is best diagnosed by manometry, which is able to correctly stratify patient groups and determine therapy. Biliary scintigraphy, which is noninvasive, has shown promise as a screening tool for patients with suspected SO dysfunction. Division of the sphincter is an effective treatment for patients with manometrically proven SO stenosis for either the biliary or pancreatic form of the disorder. Other forms of SO dysfunction may benefit from pharmacotherapy.http://dx.doi.org/10.1155/2000/313601 |
| spellingShingle | James Toouli Alexander Craig Sphincter of Oddi Function and Dysfunction Canadian Journal of Gastroenterology |
| title | Sphincter of Oddi Function and Dysfunction |
| title_full | Sphincter of Oddi Function and Dysfunction |
| title_fullStr | Sphincter of Oddi Function and Dysfunction |
| title_full_unstemmed | Sphincter of Oddi Function and Dysfunction |
| title_short | Sphincter of Oddi Function and Dysfunction |
| title_sort | sphincter of oddi function and dysfunction |
| url | http://dx.doi.org/10.1155/2000/313601 |
| work_keys_str_mv | AT jamestoouli sphincterofoddifunctionanddysfunction AT alexandercraig sphincterofoddifunctionanddysfunction |