Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin
ObjectiveTo analyze the clinical efficacy of hysterectomy and bilateral salpingo-oophorectomy (BSO) in female patients with pseudomyxoma peritonei (PMP) of an appendiceal origin as well as to identify the prognostic factors associated with overall survival (OS) to reduce adverse physical or psycholo...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1485694/full |
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| author | Fengxian Fu Xulan Ma Zhen Weng Zhen Weng Zhen Weng Zhen Weng Yiyan Lu Hongbin Xu Ruiqing Ma |
| author_facet | Fengxian Fu Xulan Ma Zhen Weng Zhen Weng Zhen Weng Zhen Weng Yiyan Lu Hongbin Xu Ruiqing Ma |
| author_sort | Fengxian Fu |
| collection | DOAJ |
| description | ObjectiveTo analyze the clinical efficacy of hysterectomy and bilateral salpingo-oophorectomy (BSO) in female patients with pseudomyxoma peritonei (PMP) of an appendiceal origin as well as to identify the prognostic factors associated with overall survival (OS) to reduce adverse physical or psychological effects on women.MethodsA retrospective analysis was conducted to evaluate the prognostic factors in female patients with PMP of an appendiceal origin who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) including BSO at our hospital between January 2011 and December 2020. Patients were also divided into high and low grade group according to pathology subtype. The data were analyzed by using Chi-square, univariate and multivariate cox regression methods, and survival was evaluated by Kaplan-Meier method.ResultsWe included 178 patients with PMP of an appendiceal origin who underwent BSO, and 134 (75.3%) had histopathological confirmed ovarian metastases. In the low-grade group, ovarian involvement and completeness of cytoreduction (CCR) acted as independent predictors of poor prognosis for OS. In normal appearing uterus, ovaries, fallopian tubes, pathologic disease was still found in 15.4%, 7.8%, and 22.8% respectively. In abnormal appearing uterus, ovaries, fallopian tubes, pathologic disease was found in 95.5%, 96.6%, and 94.2% respectively. Moreover, multivariate analysis revealed that a high-grade histopathological subtype of PMP and CCR 2/3 were independent predictors of OS.ConclusionBased on these data, strong consideration should be given to removal of gynecologic organs in cases of appendiceal peritoneal disease even when normal in appearance, after taking into account each individual patient’s fertility concerns. |
| format | Article |
| id | doaj-art-2d36063074c345d784a2ab5ce020a0e5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-2d36063074c345d784a2ab5ce020a0e52025-08-20T03:36:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.14856941485694Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal originFengxian Fu0Xulan Ma1Zhen Weng2Zhen Weng3Zhen Weng4Zhen Weng5Yiyan Lu6Hongbin Xu7Ruiqing Ma8Department of Gynecology, Aerospace Center Hospital, Beijing, ChinaDepartment of Gynecology, Aerospace Center Hospital, Beijing, ChinaMinistry of Education (MOE) Engineering Center of Hematological Disease, Soochow University, Suzhou, ChinaCyrus Tang Hematology Center, Soochow University, Suzhou, ChinaCollaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Pathology, Aerospace Center Hospital, Beijing, ChinaDepartment of Myxoma, Aerospace Center Hospital, Beijing, ChinaDepartment of Myxoma, Aerospace Center Hospital, Beijing, ChinaObjectiveTo analyze the clinical efficacy of hysterectomy and bilateral salpingo-oophorectomy (BSO) in female patients with pseudomyxoma peritonei (PMP) of an appendiceal origin as well as to identify the prognostic factors associated with overall survival (OS) to reduce adverse physical or psychological effects on women.MethodsA retrospective analysis was conducted to evaluate the prognostic factors in female patients with PMP of an appendiceal origin who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) including BSO at our hospital between January 2011 and December 2020. Patients were also divided into high and low grade group according to pathology subtype. The data were analyzed by using Chi-square, univariate and multivariate cox regression methods, and survival was evaluated by Kaplan-Meier method.ResultsWe included 178 patients with PMP of an appendiceal origin who underwent BSO, and 134 (75.3%) had histopathological confirmed ovarian metastases. In the low-grade group, ovarian involvement and completeness of cytoreduction (CCR) acted as independent predictors of poor prognosis for OS. In normal appearing uterus, ovaries, fallopian tubes, pathologic disease was still found in 15.4%, 7.8%, and 22.8% respectively. In abnormal appearing uterus, ovaries, fallopian tubes, pathologic disease was found in 95.5%, 96.6%, and 94.2% respectively. Moreover, multivariate analysis revealed that a high-grade histopathological subtype of PMP and CCR 2/3 were independent predictors of OS.ConclusionBased on these data, strong consideration should be given to removal of gynecologic organs in cases of appendiceal peritoneal disease even when normal in appearance, after taking into account each individual patient’s fertility concerns.https://www.frontiersin.org/articles/10.3389/fonc.2025.1485694/fullpseudomyxoma peritoneicytoreductive surgery plus hyperthermic intraperitoneal chemotherapyprognosishysterectomy and bilateral salpingooophorectomymacroscopic and microscopic involvement |
| spellingShingle | Fengxian Fu Xulan Ma Zhen Weng Zhen Weng Zhen Weng Zhen Weng Yiyan Lu Hongbin Xu Ruiqing Ma Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin Frontiers in Oncology pseudomyxoma peritonei cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy prognosis hysterectomy and bilateral salpingooophorectomy macroscopic and microscopic involvement |
| title | Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin |
| title_full | Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin |
| title_fullStr | Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin |
| title_full_unstemmed | Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin |
| title_short | Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin |
| title_sort | prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin |
| topic | pseudomyxoma peritonei cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy prognosis hysterectomy and bilateral salpingooophorectomy macroscopic and microscopic involvement |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1485694/full |
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