In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology
Abstract In situ radiochemical doping presents a transformative approach for synthesizing radiolabeled inorganic nanoparticles (NPs) for cancer theranostics. Traditional radiolabeling techniques rely on bifunctional chelators, which often require harsh reaction conditions that can degrade the physic...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03472-1 |
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| author | Sanchita Ghosh Yutong Liang Weibo Cai Rubel Chakravarty |
| author_facet | Sanchita Ghosh Yutong Liang Weibo Cai Rubel Chakravarty |
| author_sort | Sanchita Ghosh |
| collection | DOAJ |
| description | Abstract In situ radiochemical doping presents a transformative approach for synthesizing radiolabeled inorganic nanoparticles (NPs) for cancer theranostics. Traditional radiolabeling techniques rely on bifunctional chelators, which often require harsh reaction conditions that can degrade the physicochemical properties of NPs. Additionally, the enzymatic dissociation of radiometals can potentially induce in vivo toxicity. In contrast, in situ doping directly incorporates radiometals into the NP crystal lattice, significantly enhancing both radiolabeling yield and radiochemical stability. This method preserves the pharmacokinetic profiles of the radiolabeled NPs, improving their theranostic efficacy. This review provides an up-to-date overview of the progress made in the development of radiolabeled inorganic nanoplatforms through in situ doping, with a focus on their stability, physicochemical characteristics, and applications in cancer theranostics. Our findings highlight the advantages in situ doping as a more efficient and stable alternative to conventional radiolabeling methods, offering substantial potential for the development of more effective cancer theranostic agents. Graphical Abstract |
| format | Article |
| id | doaj-art-2d313e6a1bcb446089c692ca298c2197 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-2d313e6a1bcb446089c692ca298c21972025-08-20T03:26:47ZengBMCJournal of Nanobiotechnology1477-31552025-06-0123113610.1186/s12951-025-03472-1In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncologySanchita Ghosh0Yutong Liang1Weibo Cai2Rubel Chakravarty3Radiopharmaceuticals Division, Bhabha Atomic Research CentreMichigan State University College of Osteopathic MedicineDepartments of Radiology and Medical Physics, University of Wisconsin-MadisonRadiopharmaceuticals Division, Bhabha Atomic Research CentreAbstract In situ radiochemical doping presents a transformative approach for synthesizing radiolabeled inorganic nanoparticles (NPs) for cancer theranostics. Traditional radiolabeling techniques rely on bifunctional chelators, which often require harsh reaction conditions that can degrade the physicochemical properties of NPs. Additionally, the enzymatic dissociation of radiometals can potentially induce in vivo toxicity. In contrast, in situ doping directly incorporates radiometals into the NP crystal lattice, significantly enhancing both radiolabeling yield and radiochemical stability. This method preserves the pharmacokinetic profiles of the radiolabeled NPs, improving their theranostic efficacy. This review provides an up-to-date overview of the progress made in the development of radiolabeled inorganic nanoplatforms through in situ doping, with a focus on their stability, physicochemical characteristics, and applications in cancer theranostics. Our findings highlight the advantages in situ doping as a more efficient and stable alternative to conventional radiolabeling methods, offering substantial potential for the development of more effective cancer theranostic agents. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03472-1CancerDopingIn situNanoparticlesPrecision oncologyRadiation therapy |
| spellingShingle | Sanchita Ghosh Yutong Liang Weibo Cai Rubel Chakravarty In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology Journal of Nanobiotechnology Cancer Doping In situ Nanoparticles Precision oncology Radiation therapy |
| title | In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology |
| title_full | In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology |
| title_fullStr | In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology |
| title_full_unstemmed | In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology |
| title_short | In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology |
| title_sort | in situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications a paradigm shift in nanooncology |
| topic | Cancer Doping In situ Nanoparticles Precision oncology Radiation therapy |
| url | https://doi.org/10.1186/s12951-025-03472-1 |
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