Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis
The OBJECTIVE was to assess the effectiveness of the developed method for treating DVT with fibrinolytic agent injection via a catheter with multiple openings along the length of entire thrombus.METHODS AND MATERIALS. The analysis of treatment efficacy of 40 patients w...
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| Format: | Article |
| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2020-05-01
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| Series: | Вестник хирургии имени И.И. Грекова |
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| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/1372 |
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| author | B. S. Sukovatykh A. V. Sereditsky V. F. Muradyan A. M. Azarov M. B. Sukovatykh A. R. Khachatryan A. A. Lapinas |
| author_facet | B. S. Sukovatykh A. V. Sereditsky V. F. Muradyan A. M. Azarov M. B. Sukovatykh A. R. Khachatryan A. A. Lapinas |
| author_sort | B. S. Sukovatykh |
| collection | DOAJ |
| description | The OBJECTIVE was to assess the effectiveness of the developed method for treating DVT with fibrinolytic agent injection via a catheter with multiple openings along the length of entire thrombus.METHODS AND MATERIALS. The analysis of treatment efficacy of 40 patients with late total and subtotal deep vein thrombosis was carried out. The patients were divided into two statistically valid groups. The first group of patients weretreated using regional thrombolysis by injection of Urokinase into the popliteal vein. The second group had fibrinolytic agent injection via a catheter with multiple openings passed along the entire length of thrombosed venous segment. Patients were given Rivaroxaban before, during, and after the therapy continuously for 6 months.RESULTS. After 1 year in the second group, compared to the first group, the excellent and good results were higher by 10 % and 5 % respectively. Satisfactory and unsatisfactory results decreased by 10 and 5 % respectively. While using background Rivaroxaban, the thromboembolic complications were not registered. Hemorrhagic complications were found in 10 % of both group patients with equal rate.CONCLUSION. Injection of a fibrinolytic agent via a catheter with multiple openings along the length of entire thrombus is efficient and pathogenetically substantiated. |
| format | Article |
| id | doaj-art-2d30b2da75214aa0bd7e46ee03be6b28 |
| institution | Kabale University |
| issn | 0042-4625 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj-art-2d30b2da75214aa0bd7e46ee03be6b282025-08-20T04:00:33ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252020-05-011791202510.24884/0042-4625-2020-179-1-20-251103Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosisB. S. Sukovatykh0A. V. Sereditsky1V. F. Muradyan2A. M. Azarov3M. B. Sukovatykh4A. R. Khachatryan5A. A. Lapinas6Kursk State Medical UniversityOryol Regional Clinical HospitalOryol Regional Clinical HospitalOryol Regional Clinical HospitalKursk State Medical UniversityOryol Regional Clinical HospitalOryol Regional Clinical HospitalThe OBJECTIVE was to assess the effectiveness of the developed method for treating DVT with fibrinolytic agent injection via a catheter with multiple openings along the length of entire thrombus.METHODS AND MATERIALS. The analysis of treatment efficacy of 40 patients with late total and subtotal deep vein thrombosis was carried out. The patients were divided into two statistically valid groups. The first group of patients weretreated using regional thrombolysis by injection of Urokinase into the popliteal vein. The second group had fibrinolytic agent injection via a catheter with multiple openings passed along the entire length of thrombosed venous segment. Patients were given Rivaroxaban before, during, and after the therapy continuously for 6 months.RESULTS. After 1 year in the second group, compared to the first group, the excellent and good results were higher by 10 % and 5 % respectively. Satisfactory and unsatisfactory results decreased by 10 and 5 % respectively. While using background Rivaroxaban, the thromboembolic complications were not registered. Hemorrhagic complications were found in 10 % of both group patients with equal rate.CONCLUSION. Injection of a fibrinolytic agent via a catheter with multiple openings along the length of entire thrombus is efficient and pathogenetically substantiated.https://www.vestnik-grekova.ru/jour/article/view/1372total and subtotal thrombosisadvanced timedeep veinslower extremitiesregional urokinase thrombolysisrivaroxaban |
| spellingShingle | B. S. Sukovatykh A. V. Sereditsky V. F. Muradyan A. M. Azarov M. B. Sukovatykh A. R. Khachatryan A. A. Lapinas Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis Вестник хирургии имени И.И. Грекова total and subtotal thrombosis advanced time deep veins lower extremities regional urokinase thrombolysis rivaroxaban |
| title | Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis |
| title_full | Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis |
| title_fullStr | Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis |
| title_full_unstemmed | Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis |
| title_short | Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis |
| title_sort | efficiency of regional catheter guided thrombolysis in treatment of late total and subtotal deep vein thrombosis |
| topic | total and subtotal thrombosis advanced time deep veins lower extremities regional urokinase thrombolysis rivaroxaban |
| url | https://www.vestnik-grekova.ru/jour/article/view/1372 |
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