Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis

Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis

The  OBJECTIVE   was   to  assess the  effectiveness  of  the  developed  method  for  treating   DVT  with  fibrinolytic agent injection  via  a  catheter with  multiple  openings along  the  length  of  entire  thrombus.METHODS  AND MATERIALS. The  analysis of treatment efficacy  of 40  patients w...

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Bibliographic Details
Main Authors: B. S. Sukovatykh, A. V. Sereditsky, V. F. Muradyan, A. M. Azarov, M. B. Sukovatykh, A. R. Khachatryan, A. A. Lapinas
Format: Article
Language:Russian
Published: Pavlov First Saint Petersburg State Medical University 2020-05-01
Series:Вестник хирургии имени И.И. Грекова
Subjects:
total and subtotal thrombosis
advanced time
deep veins
lower extremities
regional urokinase thrombolysis
rivaroxaban
Online Access:https://www.vestnik-grekova.ru/jour/article/view/1372
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Summary:The  OBJECTIVE   was   to  assess the  effectiveness  of  the  developed  method  for  treating   DVT  with  fibrinolytic agent injection  via  a  catheter with  multiple  openings along  the  length  of  entire  thrombus.METHODS  AND MATERIALS. The  analysis of treatment efficacy  of 40  patients with late  total  and  subtotal deep  vein thrombosis was  carried  out.  The  patients were  divided  into two statistically  valid groups. The  first group  of patients weretreated using  regional   thrombolysis by  injection  of  Urokinase into  the  popliteal  vein.  The  second group  had  fibrinolytic agent injection  via  a  catheter with  multiple  openings passed  along   the  entire   length   of  thrombosed venous segment. Patients were  given  Rivaroxaban before, during,  and  after  the  therapy  continuously for  6  months.RESULTS.   After 1  year  in the  second group,  compared to  the  first group,  the  excellent and  good  results were  higher by  10  %  and  5  %  respectively. Satisfactory and  unsatisfactory results decreased  by  10  and  5  %  respectively.  While using  background Rivaroxaban, the  thromboembolic complications were  not  registered. Hemorrhagic complications were found  in  10  %  of  both  group  patients with  equal   rate.CONCLUSION.  Injection  of a  fibrinolytic agent via a  catheter with multiple  openings along  the  length  of entire  thrombus is  efficient  and  pathogenetically substantiated.
ISSN:0042-4625

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