Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes
Objective: This study determined the effect of topical dorzolamide versus timolol on central corneal thickness (CCT) and endothelial cell count of glaucomatous eyes. Methods: A randomized controlled trial was conducted involving 37 eyes of 37 patients diagnosed with primary open-angle glaucoma, o...
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Philippine Academy of Ophthalmology
2007-12-01
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| Series: | Philippine Journal of Ophthalmology |
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| Online Access: | https://paojournal.com/index.php/pjo/article/view/340 |
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| author | Ernesto D. Golez III, MD Manuel B. Agulto, MD Ma. Margarita L. Luna, MD |
| author_facet | Ernesto D. Golez III, MD Manuel B. Agulto, MD Ma. Margarita L. Luna, MD |
| author_sort | Ernesto D. Golez III, MD |
| collection | DOAJ |
| description | Objective: This study determined the effect of topical dorzolamide versus timolol on central corneal thickness (CCT) and endothelial cell count of glaucomatous eyes.
Methods: A randomized controlled trial was conducted involving 37 eyes of 37 patients diagnosed with primary open-angle glaucoma, ocular hypertension, normo-tensive glaucoma, pigmentary glaucoma, or pseudoexfoliative glaucoma, who may or may not be on antiglaucoma medication, and with a cup-disc ratio of <0.8 and visual acuity of 6/60 or better. All patients underwent baseline ophthalmic examination and were randomized to receive either timolol or dorzolamide instilled twice daily. Central corneal thickness (CCT) and intraocular pressure (IOP) were measured at baseline, day 1, week 1, week 2, and week 4 of treatment. Endothelial-cell count was measured at baseline and at week 4 of treatment.
Results: Thirty-four of 37 eyes were included in the analysis. The mean baseline CCT of the dorzolamide group was higher (533.9 µm ± 35.6) than that of the timolol group (511.4 ± 23.8, p = 0.02), and the difference was statistically significant. A comparison of the effect of dorzolamide versus timolol on the change in CCT over the four-week period did not show any statistically significant difference. Endothelial-cell count after 4 weeks of treatment was not statistically different between the groups. Correlation between mean IOP and mean CCT in each group was maintained during the treatment.
Conclusion: Dorzolamide did not cause a significant change in CCT and and endothelial-cell count over 1 month of treatment. |
| format | Article |
| id | doaj-art-2d309e4f38ff4489b3e0fa6298c3c3ed |
| institution | DOAJ |
| issn | 0031-7659 |
| language | English |
| publishDate | 2007-12-01 |
| publisher | Philippine Academy of Ophthalmology |
| record_format | Article |
| series | Philippine Journal of Ophthalmology |
| spelling | doaj-art-2d309e4f38ff4489b3e0fa6298c3c3ed2025-08-20T02:40:33ZengPhilippine Academy of OphthalmologyPhilippine Journal of Ophthalmology0031-76592007-12-013227680340Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyesErnesto D. Golez III, MD0Manuel B. Agulto, MD1Ma. Margarita L. Luna, MD2Department of Ophthalmology and Visual Sciences Sentro Oftalmologico Jose Rizal University of the Philippines–Philippine General Hospital Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences Sentro Oftalmologico Jose Rizal University of the Philippines–Philippine General Hospital Manila, Philippines; Institute of Ophthalmology University of the Philippines–National Institutes of Health Manila, PhilippinesDepartment of Ophthalmology and Visual Sciences Sentro Oftalmologico Jose Rizal University of the Philippines–Philippine General Hospital Manila, PhilippinesObjective: This study determined the effect of topical dorzolamide versus timolol on central corneal thickness (CCT) and endothelial cell count of glaucomatous eyes. Methods: A randomized controlled trial was conducted involving 37 eyes of 37 patients diagnosed with primary open-angle glaucoma, ocular hypertension, normo-tensive glaucoma, pigmentary glaucoma, or pseudoexfoliative glaucoma, who may or may not be on antiglaucoma medication, and with a cup-disc ratio of <0.8 and visual acuity of 6/60 or better. All patients underwent baseline ophthalmic examination and were randomized to receive either timolol or dorzolamide instilled twice daily. Central corneal thickness (CCT) and intraocular pressure (IOP) were measured at baseline, day 1, week 1, week 2, and week 4 of treatment. Endothelial-cell count was measured at baseline and at week 4 of treatment. Results: Thirty-four of 37 eyes were included in the analysis. The mean baseline CCT of the dorzolamide group was higher (533.9 µm ± 35.6) than that of the timolol group (511.4 ± 23.8, p = 0.02), and the difference was statistically significant. A comparison of the effect of dorzolamide versus timolol on the change in CCT over the four-week period did not show any statistically significant difference. Endothelial-cell count after 4 weeks of treatment was not statistically different between the groups. Correlation between mean IOP and mean CCT in each group was maintained during the treatment. Conclusion: Dorzolamide did not cause a significant change in CCT and and endothelial-cell count over 1 month of treatment.https://paojournal.com/index.php/pjo/article/view/340dorzolamidecentral corneal thicknessglaucomacarbonic anhydrase inhibitor |
| spellingShingle | Ernesto D. Golez III, MD Manuel B. Agulto, MD Ma. Margarita L. Luna, MD Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes Philippine Journal of Ophthalmology dorzolamide central corneal thickness glaucoma carbonic anhydrase inhibitor |
| title | Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes |
| title_full | Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes |
| title_fullStr | Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes |
| title_full_unstemmed | Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes |
| title_short | Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes |
| title_sort | effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial cell count of glaucomatous eyes |
| topic | dorzolamide central corneal thickness glaucoma carbonic anhydrase inhibitor |
| url | https://paojournal.com/index.php/pjo/article/view/340 |
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