Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis

Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis

BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive disorder characterized by chronic inflammation and pathological lung remodeling driven by excessive extracellular matrix deposition. While the flavonol quercetin exhibits established anti-inflammatory and antioxidant properties, its ther...

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Bibliographic Details
Main Authors: Yuejiao Lan, Cuiting Dong, Mingda Wu, Ruichen Yuan, Kunpeng Yang, Zhen Yang, Yang Chen, Jingbin Zhang, Bingxue Qi, Xiaodan Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
quercetin
FSTL1
NF-κB
EMT
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1594757/full
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