Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial
Introduction. The question of the possibility of recovery of postischemic myocardium remains relevant.Aim. The aim of the study was to study the effect of dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on the developed fibrous degeneration of the myocardium, a...
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2023-09-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/1559 |
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| author | A. I. Lebedeva S. A. Afanasiev E. M. Gareev D. S. Kondratieva L. A. Musina S. V. Popov A. V. Prusakov A. V. Yashin V. S. Ponamarev V. D. Radnatarov |
| author_facet | A. I. Lebedeva S. A. Afanasiev E. M. Gareev D. S. Kondratieva L. A. Musina S. V. Popov A. V. Prusakov A. V. Yashin V. S. Ponamarev V. D. Radnatarov |
| author_sort | A. I. Lebedeva |
| collection | DOAJ |
| description | Introduction. The question of the possibility of recovery of postischemic myocardium remains relevant.Aim. The aim of the study was to study the effect of dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on the developed fibrous degeneration of the myocardium, as well as to reveal the possible mechanisms of cellular regeneration.Materials and methods. The muscular wall of the heart of rats was subjected to cryodestruction. After 45 days, the rats of the main group were intramyocardially injected with a suspension of allogeneic biomaterialinto the area of the affected myocardium, and the rats of the control group were injected with saline.Results and discussions. In the experimental group, there was a regression of the formed fibrous connective tissue, chemoattraction of progenitor cells, their differentiation and integration into the myocardium. The thickness of the muscular part of the wall of the left ventricle was three orders of magnitude higher than in the control group.Conclusion. Analysis of the results of the study indicates that the heart in adult mammals has a powerful regenerative reserve. It is likely that, based on the use of DAB, a protocol can be developed that allows the restoration of the heart muscle even in conditions of already developed fibrous degeneration. |
| format | Article |
| id | doaj-art-2d2bac11217a4a23a1077d6361161128 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-2d2bac11217a4a23a1077d63611611282025-08-20T03:19:31ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492023-09-0112320221110.33380/2305-2066-2023-12-3-202-2111141Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic BiomaterialA. I. Lebedeva0S. A. Afanasiev1E. M. Gareev2D. S. Kondratieva3L. A. Musina4S. V. Popov5A. V. Prusakov6A. V. Yashin7V. S. Ponamarev8V. D. Radnatarov9Bashkir State Medical UniversityCardiology Research Institute, Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences"Bashkir State Medical UniversityCardiology Research Institute, Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences"Bashkir State Medical UniversityCardiology Research Institute, Federal State Budgetary Scientific Institution "Tomsk National Research Medical Center of the Russian Academy of Sciences"Saint-Petersburg State University of Veterinary MedicineSaint-Petersburg State University of Veterinary MedicineSaint-Petersburg State University of Veterinary MedicineFederal State Budgetary Educational Institution of Higher Professional Education "Buryat State Agriculture Academy by V. R. Philippov"Introduction. The question of the possibility of recovery of postischemic myocardium remains relevant.Aim. The aim of the study was to study the effect of dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on the developed fibrous degeneration of the myocardium, as well as to reveal the possible mechanisms of cellular regeneration.Materials and methods. The muscular wall of the heart of rats was subjected to cryodestruction. After 45 days, the rats of the main group were intramyocardially injected with a suspension of allogeneic biomaterialinto the area of the affected myocardium, and the rats of the control group were injected with saline.Results and discussions. In the experimental group, there was a regression of the formed fibrous connective tissue, chemoattraction of progenitor cells, their differentiation and integration into the myocardium. The thickness of the muscular part of the wall of the left ventricle was three orders of magnitude higher than in the control group.Conclusion. Analysis of the results of the study indicates that the heart in adult mammals has a powerful regenerative reserve. It is likely that, based on the use of DAB, a protocol can be developed that allows the restoration of the heart muscle even in conditions of already developed fibrous degeneration.https://www.pharmjournal.ru/jour/article/view/1559extracellular extracellular matrixcardiomyogenic cellsallogeneic biomaterialscarmyocardiumregeneration |
| spellingShingle | A. I. Lebedeva S. A. Afanasiev E. M. Gareev D. S. Kondratieva L. A. Musina S. V. Popov A. V. Prusakov A. V. Yashin V. S. Ponamarev V. D. Radnatarov Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial Разработка и регистрация лекарственных средств extracellular extracellular matrix cardiomyogenic cells allogeneic biomaterial scar myocardium regeneration |
| title | Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial |
| title_full | Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial |
| title_fullStr | Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial |
| title_full_unstemmed | Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial |
| title_short | Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial |
| title_sort | improvement of myocardial structure after developed fibrous degeneration under the use of allogenic biomaterial |
| topic | extracellular extracellular matrix cardiomyogenic cells allogeneic biomaterial scar myocardium regeneration |
| url | https://www.pharmjournal.ru/jour/article/view/1559 |
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