Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease
BackgroundIdentification of coronary ischemia in suspected coronary artery disease (CAD) remains challenging. Magnetocardiography (MCG) demonstrated comparably high diagnostic efficiency for detecting coronary ischemia in previous studies. However, limited evidence exists comparing MCG vs. computed...
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Frontiers Media S.A.
2025-07-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmedt.2025.1611046/full |
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| author | Wen-fei He Li-huan Zeng Nan-shan Xie Hao-xing Liu Hao-xing Liu Wen-min Cui Ying Wang Zhi-jian Zhang Guan-lun Ye Zhi-ying Qin Zhi-qiang Guo Jun Ma Jian-fang Luo Jian-fang Luo |
| author_facet | Wen-fei He Li-huan Zeng Nan-shan Xie Hao-xing Liu Hao-xing Liu Wen-min Cui Ying Wang Zhi-jian Zhang Guan-lun Ye Zhi-ying Qin Zhi-qiang Guo Jun Ma Jian-fang Luo Jian-fang Luo |
| author_sort | Wen-fei He |
| collection | DOAJ |
| description | BackgroundIdentification of coronary ischemia in suspected coronary artery disease (CAD) remains challenging. Magnetocardiography (MCG) demonstrated comparably high diagnostic efficiency for detecting coronary ischemia in previous studies. However, limited evidence exists comparing MCG vs. computed tomography angiography-derived fractional flow reserve (CTFFR) in suspected CAD patients.MethodsA total of 291 patients with CTA-confirmed diameter stenosis ranging from 30% to 90% were included and divided into two groups based on the CTFFR values, the stable coronary artery disease (SCAD) group (≤0.8) and the non-SCAD group (>0.8). Magnetic field map (MFM) parameters were employed to construct a diagnostic model. The performance of the models was evaluated using receiver operating characteristic (ROC) curves, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).ResultsPatients with SCAD showed a mean MCG score of 5.6 ± 2.9, while the non-SCAD group demonstrated a mean score of 2.0 ± 1.9 (P < 0.001). The area under the curve (AUC) for ROC analysis was 0.824 (95% CI: 0.772–0.877). Point 5 was selected as the operational cutoff value providing a favorable balance of sensitivity and specificity. Ultimately, MCG score yielded a sensitivity of 69.6%, specificity of 87.9%, PPV of 72.7%, NPV of 86.2%, and accuracy of 82.1%.ConclusionsCompared to CTFFR, MCG demonstrated superior specificity and moderate sensitivity for detecting CAD in patients with diameter stenosis CTA ranging from 30% to 90%. It may provide an alternative to functional evaluation prior to invasive or radiation exposure methods. |
| format | Article |
| id | doaj-art-2d1f55eb62fa421cb66d9626e0122251 |
| institution | DOAJ |
| issn | 2673-3129 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medical Technology |
| spelling | doaj-art-2d1f55eb62fa421cb66d9626e01222512025-08-20T03:13:35ZengFrontiers Media S.A.Frontiers in Medical Technology2673-31292025-07-01710.3389/fmedt.2025.16110461611046Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery diseaseWen-fei He0Li-huan Zeng1Nan-shan Xie2Hao-xing Liu3Hao-xing Liu4Wen-min Cui5Ying Wang6Zhi-jian Zhang7Guan-lun Ye8Zhi-ying Qin9Zhi-qiang Guo10Jun Ma11Jian-fang Luo12Jian-fang Luo13Department of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of General Practice, Guicheng Community Health Service Center of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaR&D Department, Shenzhen Raysight Intelligent Medical Technology Corporation, Shenzhen, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital’s Nanhai Hospital, the Second People’s Hospital of Nanhai District, Foshan, ChinaGuangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, ChinaBackgroundIdentification of coronary ischemia in suspected coronary artery disease (CAD) remains challenging. Magnetocardiography (MCG) demonstrated comparably high diagnostic efficiency for detecting coronary ischemia in previous studies. However, limited evidence exists comparing MCG vs. computed tomography angiography-derived fractional flow reserve (CTFFR) in suspected CAD patients.MethodsA total of 291 patients with CTA-confirmed diameter stenosis ranging from 30% to 90% were included and divided into two groups based on the CTFFR values, the stable coronary artery disease (SCAD) group (≤0.8) and the non-SCAD group (>0.8). Magnetic field map (MFM) parameters were employed to construct a diagnostic model. The performance of the models was evaluated using receiver operating characteristic (ROC) curves, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).ResultsPatients with SCAD showed a mean MCG score of 5.6 ± 2.9, while the non-SCAD group demonstrated a mean score of 2.0 ± 1.9 (P < 0.001). The area under the curve (AUC) for ROC analysis was 0.824 (95% CI: 0.772–0.877). Point 5 was selected as the operational cutoff value providing a favorable balance of sensitivity and specificity. Ultimately, MCG score yielded a sensitivity of 69.6%, specificity of 87.9%, PPV of 72.7%, NPV of 86.2%, and accuracy of 82.1%.ConclusionsCompared to CTFFR, MCG demonstrated superior specificity and moderate sensitivity for detecting CAD in patients with diameter stenosis CTA ranging from 30% to 90%. It may provide an alternative to functional evaluation prior to invasive or radiation exposure methods.https://www.frontiersin.org/articles/10.3389/fmedt.2025.1611046/fullmagnetocardiography (MCG)angiography-derived fractional flow reservestable coronary artery disease (SCAD)coronary ischemiaassessment |
| spellingShingle | Wen-fei He Li-huan Zeng Nan-shan Xie Hao-xing Liu Hao-xing Liu Wen-min Cui Ying Wang Zhi-jian Zhang Guan-lun Ye Zhi-ying Qin Zhi-qiang Guo Jun Ma Jian-fang Luo Jian-fang Luo Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease Frontiers in Medical Technology magnetocardiography (MCG) angiography-derived fractional flow reserve stable coronary artery disease (SCAD) coronary ischemia assessment |
| title | Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease |
| title_full | Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease |
| title_fullStr | Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease |
| title_full_unstemmed | Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease |
| title_short | Effectiveness of magnetocardiography as a non-invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease |
| title_sort | effectiveness of magnetocardiography as a non invasive tool for functional assessment of myocardial ischemia in patients with stable coronary artery disease |
| topic | magnetocardiography (MCG) angiography-derived fractional flow reserve stable coronary artery disease (SCAD) coronary ischemia assessment |
| url | https://www.frontiersin.org/articles/10.3389/fmedt.2025.1611046/full |
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