Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory
Spatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes to spatial information processing. Here, we di...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2008/258467 |
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| _version_ | 1832561901606797312 |
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| author | P. A. Lipton H. Eichenbaum |
| author_facet | P. A. Lipton H. Eichenbaum |
| author_sort | P. A. Lipton |
| collection | DOAJ |
| description | Spatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes to spatial information processing. Here, we discuss recent electrophysiological findings that offer an alternate view of hippocampal and medial entorhinal function. These findings suggest complementary contributions of the hippocampus and medial entorhinal cortex in support of episodic memory, wherein hippocampal networks encode sequences of events that compose temporally and spatially extended episodes, whereas medial entorhinal networks disambiguate overlapping episodes by binding sequential events into distinct memories. |
| format | Article |
| id | doaj-art-2d18ec4658c14ffd9c6c6d1e10516a76 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2d18ec4658c14ffd9c6c6d1e10516a762025-02-03T01:23:52ZengWileyNeural Plasticity2090-59041687-54432008-01-01200810.1155/2008/258467258467Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic MemoryP. A. Lipton0H. Eichenbaum1Center for Memory and Brain, Department of Psychology, Boston University, 2 Cummington street, Boston, MA 02215, USACenter for Memory and Brain, Department of Psychology, Boston University, 2 Cummington street, Boston, MA 02215, USASpatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes to spatial information processing. Here, we discuss recent electrophysiological findings that offer an alternate view of hippocampal and medial entorhinal function. These findings suggest complementary contributions of the hippocampus and medial entorhinal cortex in support of episodic memory, wherein hippocampal networks encode sequences of events that compose temporally and spatially extended episodes, whereas medial entorhinal networks disambiguate overlapping episodes by binding sequential events into distinct memories.http://dx.doi.org/10.1155/2008/258467 |
| spellingShingle | P. A. Lipton H. Eichenbaum Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory Neural Plasticity |
| title | Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory |
| title_full | Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory |
| title_fullStr | Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory |
| title_full_unstemmed | Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory |
| title_short | Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory |
| title_sort | complementary roles of hippocampus and medial entorhinal cortex in episodic memory |
| url | http://dx.doi.org/10.1155/2008/258467 |
| work_keys_str_mv | AT palipton complementaryrolesofhippocampusandmedialentorhinalcortexinepisodicmemory AT heichenbaum complementaryrolesofhippocampusandmedialentorhinalcortexinepisodicmemory |