The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease
PURPOSE Chronic kidney disease (CKD) is a major global health issue characterized by a gradual and irreversible decline in renal function. Despite its increasing prevalence, effective therapeutic options remain limited, highlighting the need for novel treatment approaches. This review highlights the...
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| Format: | Article |
| Language: | Korean |
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The Korean Society of Exercise Physiology
2024-11-01
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| Series: | 운동과학 |
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| Online Access: | http://ksep-es.org/upload/pdf/ksep-2024-00472.pdf |
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| author | Jae Seung Chang |
| author_facet | Jae Seung Chang |
| author_sort | Jae Seung Chang |
| collection | DOAJ |
| description | PURPOSE Chronic kidney disease (CKD) is a major global health issue characterized by a gradual and irreversible decline in renal function. Despite its increasing prevalence, effective therapeutic options remain limited, highlighting the need for novel treatment approaches. This review highlights the importance of exercise as a nonpharmacological intervention by exploring the role of exercise-induced bioactive molecules in CKD management. METHODS An extensive literature review was conducted using PubMed, Scopus, Web of Science, and Google Scholar. The search terms included “myokine,” “exerkine,” “chronic kidney disease,” “nephropathy,” “renal function,” “podocyte,” “mesangial cell,” “exercise,” “physical activity,” and other related terms. RESULTS Exercise-induced molecules, particularly myokines and exerkines, can slow the progression of CKD through protective mechanisms. These molecules reduce oxidative stress via antioxidant defense pathways, regulate immune responses to limit inflammation, and inhibit fibrotic signaling by interacting with TGF-β and other pro-fibrotic factors. Furthermore, they preserve renal function by maintaining podocyte and mesangial cell integrity and modulating autophagy, thereby preventing kidney damage. CONCLUSIONS This review consolidates the current knowledge on the therapeutic potential and diverse functions of exercise-induced molecules in CKD, offering insights into their ability to slow disease progression and improve patient outcomes through nonpharmacological strategies. |
| format | Article |
| id | doaj-art-2d16240df6134981bcb135d5bebf22b0 |
| institution | OA Journals |
| issn | 1226-1726 2384-0544 |
| language | Korean |
| publishDate | 2024-11-01 |
| publisher | The Korean Society of Exercise Physiology |
| record_format | Article |
| series | 운동과학 |
| spelling | doaj-art-2d16240df6134981bcb135d5bebf22b02025-08-20T02:32:10ZkorThe Korean Society of Exercise Physiology운동과학1226-17262384-05442024-11-0133436637910.15857/ksep.2024.004721110The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney DiseaseJae Seung Chang0Department of Sports Science, Hannam University, Daejeon, KoreaPURPOSE Chronic kidney disease (CKD) is a major global health issue characterized by a gradual and irreversible decline in renal function. Despite its increasing prevalence, effective therapeutic options remain limited, highlighting the need for novel treatment approaches. This review highlights the importance of exercise as a nonpharmacological intervention by exploring the role of exercise-induced bioactive molecules in CKD management. METHODS An extensive literature review was conducted using PubMed, Scopus, Web of Science, and Google Scholar. The search terms included “myokine,” “exerkine,” “chronic kidney disease,” “nephropathy,” “renal function,” “podocyte,” “mesangial cell,” “exercise,” “physical activity,” and other related terms. RESULTS Exercise-induced molecules, particularly myokines and exerkines, can slow the progression of CKD through protective mechanisms. These molecules reduce oxidative stress via antioxidant defense pathways, regulate immune responses to limit inflammation, and inhibit fibrotic signaling by interacting with TGF-β and other pro-fibrotic factors. Furthermore, they preserve renal function by maintaining podocyte and mesangial cell integrity and modulating autophagy, thereby preventing kidney damage. CONCLUSIONS This review consolidates the current knowledge on the therapeutic potential and diverse functions of exercise-induced molecules in CKD, offering insights into their ability to slow disease progression and improve patient outcomes through nonpharmacological strategies.http://ksep-es.org/upload/pdf/ksep-2024-00472.pdfmyokineexerkinechronic kidney disease |
| spellingShingle | Jae Seung Chang The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease 운동과학 myokine exerkine chronic kidney disease |
| title | The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease |
| title_full | The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease |
| title_fullStr | The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease |
| title_full_unstemmed | The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease |
| title_short | The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease |
| title_sort | potential protective mechanisms of exercise responsive molecules in chronic kidney disease |
| topic | myokine exerkine chronic kidney disease |
| url | http://ksep-es.org/upload/pdf/ksep-2024-00472.pdf |
| work_keys_str_mv | AT jaeseungchang thepotentialprotectivemechanismsofexerciseresponsivemoleculesinchronickidneydisease AT jaeseungchang potentialprotectivemechanismsofexerciseresponsivemoleculesinchronickidneydisease |