SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE
The aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR an...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Sebelas Maret
2017-03-01
|
| Series: | Alchemy |
| Subjects: | |
| Online Access: | https://jurnal.uns.ac.id/alchemy/article/view/4324 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850038455294230528 |
|---|---|
| author | Susy Yunita Prabawati Arifah Khusnuryani Khamidinal |
| author_facet | Susy Yunita Prabawati Arifah Khusnuryani Khamidinal |
| author_sort | Susy Yunita Prabawati |
| collection | DOAJ |
| description | The aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR and 1H-NMR spectrometer. The product was obtained as a orange solid which has a melting point at 58-59 ˚C. Identification of the product by IR spectrophotometer showed the absorption of C=C in the wavenumber of 1496.76 cm-1 which confirmed that the hydration reaction of chalcone had occurred. Analysis using 1H-NMR spectrometer also showed the proton of the CH=CH appearing on chemical shift (δ) 7.99 ppm. The antibacterial activity test showed that the compounds of 3-methoxy-4-hydroxychalcone has a potential as an antibacterial against bacteria E. coli and B. subtilis. |
| format | Article |
| id | doaj-art-2d108eaca40a4e2d9d7436c7e301f610 |
| institution | DOAJ |
| issn | 1412-4092 2443-4183 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Universitas Sebelas Maret |
| record_format | Article |
| series | Alchemy |
| spelling | doaj-art-2d108eaca40a4e2d9d7436c7e301f6102025-08-20T02:56:36ZengUniversitas Sebelas MaretAlchemy1412-40922443-41832017-03-011319510210.20961/alchemy.v13i1.4324SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCESusy Yunita Prabawati0Arifah Khusnuryani1Khamidinal2Program Studi Kimia, Fakultas Sains danTeknologi UIN Sunan Kalijaga YogyakartaProgram Studi Biologi, Fakultas Sains danTeknologi UIN Sunan Kalijaga YogyakartaProgram Studi Kimia, Fakultas Sains danTeknologi UIN Sunan Kalijaga YogyakartaThe aims of this study was to synthesize a compound of 3-methoxy-4-hydroxychalcone through Claisen-Schmidt condensation with grinding technique (solvent-free). Vanillin, acetophenone and 60 % NaOH catalyst used in this synthesis. Characterization of products was done with a spectrophotometer FTIR and 1H-NMR spectrometer. The product was obtained as a orange solid which has a melting point at 58-59 ˚C. Identification of the product by IR spectrophotometer showed the absorption of C=C in the wavenumber of 1496.76 cm-1 which confirmed that the hydration reaction of chalcone had occurred. Analysis using 1H-NMR spectrometer also showed the proton of the CH=CH appearing on chemical shift (δ) 7.99 ppm. The antibacterial activity test showed that the compounds of 3-methoxy-4-hydroxychalcone has a potential as an antibacterial against bacteria E. coli and B. subtilis.https://jurnal.uns.ac.id/alchemy/article/view/4324antibacterialgrinding techniquevanillin3-methoxy-4-hydroxychalcone |
| spellingShingle | Susy Yunita Prabawati Arifah Khusnuryani Khamidinal SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE Alchemy antibacterial grinding technique vanillin 3-methoxy-4-hydroxychalcone |
| title | SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE |
| title_full | SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE |
| title_fullStr | SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE |
| title_full_unstemmed | SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE |
| title_short | SOLVENT FREE SYNTHESIS OF CHALCONE AS ANTIBACTERIAL SUBSTANCE |
| title_sort | solvent free synthesis of chalcone as antibacterial substance |
| topic | antibacterial grinding technique vanillin 3-methoxy-4-hydroxychalcone |
| url | https://jurnal.uns.ac.id/alchemy/article/view/4324 |
| work_keys_str_mv | AT susyyunitaprabawati solventfreesynthesisofchalconeasantibacterialsubstance AT arifahkhusnuryani solventfreesynthesisofchalconeasantibacterialsubstance AT khamidinal solventfreesynthesisofchalconeasantibacterialsubstance |