IL-7 armed binary CAR T cell strategy to augment potency against solid tumors

IL-7 armed binary CAR T cell strategy to augment potency against solid tumors

IntroductionClinical studies of T cells engineered with chimeric antigen receptor (CAR) targeting CD19 in B-cell malignancies have demonstrated that relapse due to target antigen (CD19) loss or limited CAR T cell persistence is a common occurrence. The possibility of such events is greater in solid...

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Bibliographic Details
Main Authors: Alejandro G. Torres Chavez, Mary K. McKenna, Anmol Gupta, Neha Daga, Juan Vera, Ann M. Leen, Pradip Bajgain
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
T-cell therapy
IL-7
IL-7R
solid tumor
pancreatic cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618404/full
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