Ontogenisis of Merkel-cell carcinoma
A narrative review was performed to clarify the ontogenesis of Merkel-cell carcinoma. It is hypothesized that the cells are derived from the embryonic neural crest, skin stem cells, epithelial cells, pre-/pro-B cells, dermal fibroblasts, or metastatic cells from other types of carcinomas. The influe...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia (SBD)
2025-04-01
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| Series: | Surgical & Cosmetic Dermatology |
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| Online Access: | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250354.pdf |
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| author | Fernanda Guimarães Souza Daniela Pessanha dos Santos Luiza Oliveira Ribeiro Thiago Rubim Batista Bellot Nascimento Flávio Barbosa Luz |
| author_facet | Fernanda Guimarães Souza Daniela Pessanha dos Santos Luiza Oliveira Ribeiro Thiago Rubim Batista Bellot Nascimento Flávio Barbosa Luz |
| author_sort | Fernanda Guimarães Souza |
| collection | DOAJ |
| description | A narrative review was performed to clarify the ontogenesis of Merkel-cell carcinoma. It is hypothesized that the cells are derived from the embryonic neural crest, skin stem cells, epithelial cells, pre-/pro-B cells, dermal fibroblasts, or metastatic cells from other types of carcinomas. The influence of epigenetics was also considered. Methodologically, to prepare the summary articles were selected from the PubMed and SciELO databases and cited references. The results suggest that it is more likely that Merkel-cell carcinoma has multiple origins, possibly from poorly differentiated cells. |
| format | Article |
| id | doaj-art-2d0d66eda5224e26a980d2a4685c4b8d |
| institution | DOAJ |
| issn | 1984-8773 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Brasileira de Dermatologia (SBD) |
| record_format | Article |
| series | Surgical & Cosmetic Dermatology |
| spelling | doaj-art-2d0d66eda5224e26a980d2a4685c4b8d2025-08-20T03:08:55ZengSociedade Brasileira de Dermatologia (SBD)Surgical & Cosmetic Dermatology1984-87732025-04-011710.5935/scd1984-8773.2025170354Ontogenisis of Merkel-cell carcinomaFernanda Guimarães Souza0Daniela Pessanha dos Santos1Luiza Oliveira Ribeiro2Thiago Rubim Batista Bellot Nascimento3Flávio Barbosa Luz4Universidade Federal Fluminense, Discente da Faculdade de Medicina, Hospital Universitário Antônio Pedro, Niterói (RJ), BrasilUniversidade Federal Fluminense, Discente da Faculdade de Medicina, Hospital Universitário Antônio Pedro, Niterói (RJ), BrasilUniversidade Federal Fluminense, Discente da Faculdade de Medicina, Hospital Universitário Antônio Pedro, Niterói (RJ), BrasilUniversidade Federal Fluminense, Doutorando em Patologia, Hospital Universitário Antônio Pedro, Niterói (RJ), BrasilUniversidade Federal Fluminense, Professor Adjunto da Faculdade de Medicina, Hospital Universitário Antônio Pedro, Niterói (RJ), BrasilA narrative review was performed to clarify the ontogenesis of Merkel-cell carcinoma. It is hypothesized that the cells are derived from the embryonic neural crest, skin stem cells, epithelial cells, pre-/pro-B cells, dermal fibroblasts, or metastatic cells from other types of carcinomas. The influence of epigenetics was also considered. Methodologically, to prepare the summary articles were selected from the PubMed and SciELO databases and cited references. The results suggest that it is more likely that Merkel-cell carcinoma has multiple origins, possibly from poorly differentiated cells.http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250354.pdfcell lineagecarcinoma, merkel cellmerkel cellsmedical oncology |
| spellingShingle | Fernanda Guimarães Souza Daniela Pessanha dos Santos Luiza Oliveira Ribeiro Thiago Rubim Batista Bellot Nascimento Flávio Barbosa Luz Ontogenisis of Merkel-cell carcinoma Surgical & Cosmetic Dermatology cell lineage carcinoma, merkel cell merkel cells medical oncology |
| title | Ontogenisis of Merkel-cell carcinoma |
| title_full | Ontogenisis of Merkel-cell carcinoma |
| title_fullStr | Ontogenisis of Merkel-cell carcinoma |
| title_full_unstemmed | Ontogenisis of Merkel-cell carcinoma |
| title_short | Ontogenisis of Merkel-cell carcinoma |
| title_sort | ontogenisis of merkel cell carcinoma |
| topic | cell lineage carcinoma, merkel cell merkel cells medical oncology |
| url | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17e20250354.pdf |
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