Personality dimensions as determinants of breast cancer progression and quality of life
Abstract Background Patients newly diagnosed with breast cancer often experience varied psychosocial responses and treatment outcomes, potentially influenced by personality traits. Understanding these traits can help clinicians predict psychological reactions and tailor early psychiatric or psycholo...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | Middle East Current Psychiatry |
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| Online Access: | https://doi.org/10.1186/s43045-025-00557-3 |
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| author | Ali Talaei Fatemeh Homaei Shandiz Elham Ghaffari Asma Khorshi Shamshiri Sahar Omidvar-Tehrani Fahimeh Afzaljavan |
| author_facet | Ali Talaei Fatemeh Homaei Shandiz Elham Ghaffari Asma Khorshi Shamshiri Sahar Omidvar-Tehrani Fahimeh Afzaljavan |
| author_sort | Ali Talaei |
| collection | DOAJ |
| description | Abstract Background Patients newly diagnosed with breast cancer often experience varied psychosocial responses and treatment outcomes, potentially influenced by personality traits. Understanding these traits can help clinicians predict psychological reactions and tailor early psychiatric or psychological interventions. This study examines the link between personality dimensions, breast cancer prognosis, and quality of life. Methods In a comparative cross-sectional study conducted in Northeast Iran, 130 breast cancer patients and 158 healthy individuals completed demographic and Cloninger Temperament and Character Inventory questionnaires. Patients also completed the EORTC QLQ-BR23 quality of life questionnaire. Clinical data and progression-free survival were obtained from medical records. Data analysis was conducted using SPSS v16. Results Breast cancer patients had significantly higher self-transcendence scores than the healthy group (p < 0.001, effect size = 7%). High cooperativeness (p = 0.008) was higher in patients, whereas low harm avoidance (p < 0.001), novelty seeking (p = 0.013), persistence (p = 0.012), and self-transcendence (p = 0.021) were lower compared to controls. Additionally, global health was significantly lower in low reward dependency (p = 0.018, effect size = 6%) and persistence (p = 0.005, effect size = 8%) than normal scores. Survival analysis indicated that high harm avoidance was associated with an elevated hazard rate [p = 0.033, HR = 4.72, 95%CI (1.14–19.58)], whereas high self-transcendence correlated with a reduced hazard rate of disease progression [p = 0.015, HR = 0.27, 95%CI (0.09–0.77)]. Conclusion Personality traits significantly influence breast cancer progression and quality of life. The study highlights the potential for integrating early psychological risk assessments and personalized psychotherapy interventions to enhance the psychological well-being of breast cancer patients, offering a proactive approach to supportive care. |
| format | Article |
| id | doaj-art-2d0b521b9ff0496ea7a95db50de6cb73 |
| institution | Kabale University |
| issn | 2090-5416 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Current Psychiatry |
| spelling | doaj-art-2d0b521b9ff0496ea7a95db50de6cb732025-08-20T04:01:42ZengSpringerOpenMiddle East Current Psychiatry2090-54162025-07-013211810.1186/s43045-025-00557-3Personality dimensions as determinants of breast cancer progression and quality of lifeAli Talaei0Fatemeh Homaei Shandiz1Elham Ghaffari2Asma Khorshi Shamshiri3Sahar Omidvar-Tehrani4Fahimeh Afzaljavan5Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical SciencesCancer Research Center, Mashhad University of Medical SciencesDepartment of Clinical Psychology, Faculty of Medicine, International Branch, Islamic Azad UniversityDepartment of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical SciencesPsychiatry and Behavioral Sciences Research Center, Mashhad University of Medical SciencesPsychiatry and Behavioral Sciences Research Center, Mashhad University of Medical SciencesAbstract Background Patients newly diagnosed with breast cancer often experience varied psychosocial responses and treatment outcomes, potentially influenced by personality traits. Understanding these traits can help clinicians predict psychological reactions and tailor early psychiatric or psychological interventions. This study examines the link between personality dimensions, breast cancer prognosis, and quality of life. Methods In a comparative cross-sectional study conducted in Northeast Iran, 130 breast cancer patients and 158 healthy individuals completed demographic and Cloninger Temperament and Character Inventory questionnaires. Patients also completed the EORTC QLQ-BR23 quality of life questionnaire. Clinical data and progression-free survival were obtained from medical records. Data analysis was conducted using SPSS v16. Results Breast cancer patients had significantly higher self-transcendence scores than the healthy group (p < 0.001, effect size = 7%). High cooperativeness (p = 0.008) was higher in patients, whereas low harm avoidance (p < 0.001), novelty seeking (p = 0.013), persistence (p = 0.012), and self-transcendence (p = 0.021) were lower compared to controls. Additionally, global health was significantly lower in low reward dependency (p = 0.018, effect size = 6%) and persistence (p = 0.005, effect size = 8%) than normal scores. Survival analysis indicated that high harm avoidance was associated with an elevated hazard rate [p = 0.033, HR = 4.72, 95%CI (1.14–19.58)], whereas high self-transcendence correlated with a reduced hazard rate of disease progression [p = 0.015, HR = 0.27, 95%CI (0.09–0.77)]. Conclusion Personality traits significantly influence breast cancer progression and quality of life. The study highlights the potential for integrating early psychological risk assessments and personalized psychotherapy interventions to enhance the psychological well-being of breast cancer patients, offering a proactive approach to supportive care.https://doi.org/10.1186/s43045-025-00557-3Breast neoplasmMiddle EastPersonalityPsycho-oncologyOutcomeTCI |
| spellingShingle | Ali Talaei Fatemeh Homaei Shandiz Elham Ghaffari Asma Khorshi Shamshiri Sahar Omidvar-Tehrani Fahimeh Afzaljavan Personality dimensions as determinants of breast cancer progression and quality of life Middle East Current Psychiatry Breast neoplasm Middle East Personality Psycho-oncology Outcome TCI |
| title | Personality dimensions as determinants of breast cancer progression and quality of life |
| title_full | Personality dimensions as determinants of breast cancer progression and quality of life |
| title_fullStr | Personality dimensions as determinants of breast cancer progression and quality of life |
| title_full_unstemmed | Personality dimensions as determinants of breast cancer progression and quality of life |
| title_short | Personality dimensions as determinants of breast cancer progression and quality of life |
| title_sort | personality dimensions as determinants of breast cancer progression and quality of life |
| topic | Breast neoplasm Middle East Personality Psycho-oncology Outcome TCI |
| url | https://doi.org/10.1186/s43045-025-00557-3 |
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