Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level
Background: Resting tremor in Parkinson’s disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024003034 |
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| author | Yuke Zhong Ying Liu Huahua Su Hang Liu Guohui Liu Zhihui Liu Jiahao Wei Junyi Wang Yuchen She Changhong Tan Lijuan Mo Lin Han Fen Deng Xi Liu Lifen Chen |
| author_facet | Yuke Zhong Ying Liu Huahua Su Hang Liu Guohui Liu Zhihui Liu Jiahao Wei Junyi Wang Yuchen She Changhong Tan Lijuan Mo Lin Han Fen Deng Xi Liu Lifen Chen |
| author_sort | Yuke Zhong |
| collection | DOAJ |
| description | Background: Resting tremor in Parkinson’s disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity, remains limited. Methods: We investigated the structural change in PD patients with resting tremor (PD-WR) from a network perspective. 42 early-stage PD-WR, 27 PD patients without resting tremor (PD-NR), and 56 healthy controls (HC) were included. Results: PD-WR showed lower cortical thickness in several motor-related lobules. Compared to HC, significant atrophy was found in right lobule VIIA (t = -3.076, p = 0.016, Cohen's d = 0.627), left lobule VI (t = -3.323, p = 0.007, Cohen's d = 0.678), and right lobule VI (t = -3.052, p = 0.017, Cohen's d = 0.623) in PD-WR. Compared to PD-NR, left lobule V also had a significant reduction (t = -2.958, p = 0.023, d = −0.657). PD-WR had higher fractional anisotropy in cerebello-cortical connection compared to HC (t = 3.209, p = 0.009, d = 0.926), with reduced radial (t = -2.561, p = 0.046, d = 0.739) and mean (t = 2.614, p = 0.046, d = 0.871) diffusivity compared to PD-NR. At the network level, better hierarchy (rho = 0.598, p = 0.004), small-worldness (rho = 0.621, p = 0.003), and increased nodal involvement of the thalamus (rho = 0.718, p = 0.031) and motor cortex (rho = 0.660, p = 0.055) were positively correlated with tremor amplitude. Conclusion: Our study supports the alternation of the cerebello-thalamo-cortical circuit in PD-WR. However, further research with other forms of PD, a wide range of disease stage and larger sample size is needed. |
| format | Article |
| id | doaj-art-2d065c556da24c74a80c2ae3d92d8373 |
| institution | OA Journals |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-2d065c556da24c74a80c2ae3d92d83732025-08-20T02:36:12ZengElsevierBrain Research Bulletin1873-27472025-01-0122011116910.1016/j.brainresbull.2024.111169Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network levelYuke Zhong0Ying Liu1Huahua Su2Hang Liu3Guohui Liu4Zhihui Liu5Jiahao Wei6Junyi Wang7Yuchen She8Changhong Tan9Lijuan Mo10Lin Han11Fen Deng12Xi Liu13Lifen Chen14Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaCorrespondence to: 74 Linjiang Road, Yuzhong District, Chongqing 400010, China.; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaCorrespondence to: 74 Linjiang Road, Yuzhong District, Chongqing 400010, China.; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, ChinaBackground: Resting tremor in Parkinson’s disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity, remains limited. Methods: We investigated the structural change in PD patients with resting tremor (PD-WR) from a network perspective. 42 early-stage PD-WR, 27 PD patients without resting tremor (PD-NR), and 56 healthy controls (HC) were included. Results: PD-WR showed lower cortical thickness in several motor-related lobules. Compared to HC, significant atrophy was found in right lobule VIIA (t = -3.076, p = 0.016, Cohen's d = 0.627), left lobule VI (t = -3.323, p = 0.007, Cohen's d = 0.678), and right lobule VI (t = -3.052, p = 0.017, Cohen's d = 0.623) in PD-WR. Compared to PD-NR, left lobule V also had a significant reduction (t = -2.958, p = 0.023, d = −0.657). PD-WR had higher fractional anisotropy in cerebello-cortical connection compared to HC (t = 3.209, p = 0.009, d = 0.926), with reduced radial (t = -2.561, p = 0.046, d = 0.739) and mean (t = 2.614, p = 0.046, d = 0.871) diffusivity compared to PD-NR. At the network level, better hierarchy (rho = 0.598, p = 0.004), small-worldness (rho = 0.621, p = 0.003), and increased nodal involvement of the thalamus (rho = 0.718, p = 0.031) and motor cortex (rho = 0.660, p = 0.055) were positively correlated with tremor amplitude. Conclusion: Our study supports the alternation of the cerebello-thalamo-cortical circuit in PD-WR. However, further research with other forms of PD, a wide range of disease stage and larger sample size is needed.http://www.sciencedirect.com/science/article/pii/S0361923024003034Resting tremorParkinson’s diseaseDimmer switch modelBrain network |
| spellingShingle | Yuke Zhong Ying Liu Huahua Su Hang Liu Guohui Liu Zhihui Liu Jiahao Wei Junyi Wang Yuchen She Changhong Tan Lijuan Mo Lin Han Fen Deng Xi Liu Lifen Chen Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level Brain Research Bulletin Resting tremor Parkinson’s disease Dimmer switch model Brain network |
| title | Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level |
| title_full | Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level |
| title_fullStr | Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level |
| title_full_unstemmed | Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level |
| title_short | Structural changes in early-stage Parkinson’s disease with resting tremor at node, edge and network level |
| title_sort | structural changes in early stage parkinson s disease with resting tremor at node edge and network level |
| topic | Resting tremor Parkinson’s disease Dimmer switch model Brain network |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024003034 |
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