Effect of YAP/TAZ in Hippo signaling pathway on renal disease
As an evolutionarily highly conserved signaling transduction pathway， Hippo signaling controls cell proliferation， apoptosis and migration， regulates organ growth and tissue repair and induces carcinogenesis. Under normal circumstances， Hippo pathway maintains normal development and homeostasis of r...
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| Format: | Article |
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Editorial Department of Journal of Clinical Nephrology
2022-08-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.08.010 |
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| _version_ | 1850187166845501440 |
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| author | Shang-heng Fan Jun Li |
| author_facet | Shang-heng Fan Jun Li |
| author_sort | Shang-heng Fan |
| collection | DOAJ |
| description | As an evolutionarily highly conserved signaling transduction pathway， Hippo signaling controls cell proliferation， apoptosis and migration， regulates organ growth and tissue repair and induces carcinogenesis. Under normal circumstances， Hippo pathway maintains normal development and homeostasis of renal tissue. During continuous stimulations of external factors， the pathway mediates the development of renal disease through mediating renal tissue injury and repair， renal cell proliferation and apoptosis. This review summarized the roles of this pathway in acute renal injury， chronic kidney disease， polycystic kidney disease， diabetic nephropathy， renal cell carcinoma and other diseases. Also the related pathway inhibitors were also discussed for identifying new therapeutic targets and strategies. |
| format | Article |
| id | doaj-art-2d03c837a5834d9986e32ce3bd0a9eac |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-08-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-2d03c837a5834d9986e32ce3bd0a9eac2025-08-20T02:16:10ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-08-012268168529547908Effect of YAP/TAZ in Hippo signaling pathway on renal diseaseShang-heng FanJun LiAs an evolutionarily highly conserved signaling transduction pathway， Hippo signaling controls cell proliferation， apoptosis and migration， regulates organ growth and tissue repair and induces carcinogenesis. Under normal circumstances， Hippo pathway maintains normal development and homeostasis of renal tissue. During continuous stimulations of external factors， the pathway mediates the development of renal disease through mediating renal tissue injury and repair， renal cell proliferation and apoptosis. This review summarized the roles of this pathway in acute renal injury， chronic kidney disease， polycystic kidney disease， diabetic nephropathy， renal cell carcinoma and other diseases. Also the related pathway inhibitors were also discussed for identifying new therapeutic targets and strategies.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.08.010Hippo signaling pathwayYes-associated proteinTAZRenal tubular epithelial cellRenal disease |
| spellingShingle | Shang-heng Fan Jun Li Effect of YAP/TAZ in Hippo signaling pathway on renal disease Linchuang shenzangbing zazhi Hippo signaling pathway Yes-associated protein TAZ Renal tubular epithelial cell Renal disease |
| title | Effect of YAP/TAZ in Hippo signaling pathway on renal disease |
| title_full | Effect of YAP/TAZ in Hippo signaling pathway on renal disease |
| title_fullStr | Effect of YAP/TAZ in Hippo signaling pathway on renal disease |
| title_full_unstemmed | Effect of YAP/TAZ in Hippo signaling pathway on renal disease |
| title_short | Effect of YAP/TAZ in Hippo signaling pathway on renal disease |
| title_sort | effect of yap taz in hippo signaling pathway on renal disease |
| topic | Hippo signaling pathway Yes-associated protein TAZ Renal tubular epithelial cell Renal disease |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.08.010 |
| work_keys_str_mv | AT shanghengfan effectofyaptazinhipposignalingpathwayonrenaldisease AT junli effectofyaptazinhipposignalingpathwayonrenaldisease |