Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway
Hyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2024-1097 |
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| author | Zeng Wen Deng Zhuyu Li Huaying Gao Shuqiang Ju Rong |
| author_facet | Zeng Wen Deng Zhuyu Li Huaying Gao Shuqiang Ju Rong |
| author_sort | Zeng Wen |
| collection | DOAJ |
| description | Hyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage to human pulmonary microvascular endothelial cells (HPMVECs) via the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) pathway. |
| format | Article |
| id | doaj-art-2d009156f450494fa78da30409d11bc9 |
| institution | OA Journals |
| issn | 2391-5463 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-2d009156f450494fa78da30409d11bc92025-08-20T02:22:11ZengDe GruyterOpen Medicine2391-54632024-12-0119110395110.1515/med-2024-1097Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathwayZeng Wen0Deng Zhuyu1Li Huaying2Gao Shuqiang3Ju Rong4Department of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan, ChinaDepartment of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan, ChinaDepartment of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan, ChinaDepartment of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan, ChinaDepartment of Neonatology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan, ChinaHyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage to human pulmonary microvascular endothelial cells (HPMVECs) via the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) pathway.https://doi.org/10.1515/med-2024-1097hyperoxiap2x7 receptornlrp3 inflammasomepyroptosispulmonary microvascular endothelial cell |
| spellingShingle | Zeng Wen Deng Zhuyu Li Huaying Gao Shuqiang Ju Rong Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway Open Medicine hyperoxia p2x7 receptor nlrp3 inflammasome pyroptosis pulmonary microvascular endothelial cell |
| title | Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway |
| title_full | Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway |
| title_fullStr | Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway |
| title_full_unstemmed | Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway |
| title_short | Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway |
| title_sort | purinergic p2x7 receptor mediates hyperoxia induced injury in pulmonary microvascular endothelial cells via nlrp3 mediated pyroptotic pathway |
| topic | hyperoxia p2x7 receptor nlrp3 inflammasome pyroptosis pulmonary microvascular endothelial cell |
| url | https://doi.org/10.1515/med-2024-1097 |
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