Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway

Purinergic P2X7 receptor mediates hyperoxia-induced injury in pulmonary microvascular endothelial cells via NLRP3-mediated pyroptotic pathway

Hyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage...

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Bibliographic Details
Main Authors: Zeng Wen, Deng Zhuyu, Li Huaying, Gao Shuqiang, Ju Rong
Format: Article
Language:English
Published: De Gruyter 2024-12-01
Series:Open Medicine
Subjects:
hyperoxia
p2x7 receptor
nlrp3 inflammasome
pyroptosis
pulmonary microvascular endothelial cell
Online Access:https://doi.org/10.1515/med-2024-1097
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Summary:Hyperoxia-induced injury is a well-recognized cause of bronchopulmonary dysplasia (BPD). Existing research studies have not well elucidated the exact mechanisms underlying hyperoxia-induced cellular damage. This study examines the involvement of the P2X7 receptor (P2X7R) in hyperoxia-induced damage to human pulmonary microvascular endothelial cells (HPMVECs) via the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) pathway.
ISSN:2391-5463

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