Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials.
Primary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase the risk of fracture. We conducted the systematic review to evaluate the effects of moxibustion for POP in randomized controlled trials (RCTs).Eight databases were searched fro...
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| Format: | Article |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0178688 |
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| author | Fanping Xu Minghua Huang Yi Jin Qingzhe Kong Zhongmin Lei Xu Wei |
| author_facet | Fanping Xu Minghua Huang Yi Jin Qingzhe Kong Zhongmin Lei Xu Wei |
| author_sort | Fanping Xu |
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| description | Primary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase the risk of fracture. We conducted the systematic review to evaluate the effects of moxibustion for POP in randomized controlled trials (RCTs).Eight databases were searched from their inception to July 30, 2016. The RCTs reporting the moxibustion as a monotherapy or in combination with conventional therapy for POP were enrolled. The outcomes might be fracture incidence, quality of life, clinical symptoms, death attributed to osteoporosis, adverse effect, bone mineral density (BMD), and biochemical indicators. Literature selection, data abstraction, quality evaluation, and data analysis were in accordance with Cochrane standards.Thirteen trials including 808 patients were included. Meta-analysis was not conducted because of the obvious clinical or statistical heterogeneity. Limited evidence suggested that moxibustion plus anti-osteoporosis medicine might be more effective in relieving the pain (visual analogue scale scores average changed 2 scores between groups, 4 trials), increasing the BMD of femoral neck (average changed 0.4 g/cm2 between groups, 3 trials), and improving the level of bone gla protein, osteoprotegerin and bone alkaline phosphatase (2 trials) compared with anti-osteoporosis medicine alone. However, the quality of previous studies was evaluated as generally poor. The safety evidence of moxibustion was still insufficient. Due to the paucity of high-quality studies, there was no definite conclusion about the efficacy and safety of moxibustion treating POP although parts of positive results were presented. Future research should pay attention to the dose-response relation and fracture incidence of moxibustion for POP. |
| format | Article |
| id | doaj-art-2cf6c0361b1348f48cf65fbe2dac0a37 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-2cf6c0361b1348f48cf65fbe2dac0a372025-08-20T03:26:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017868810.1371/journal.pone.0178688Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials.Fanping XuMinghua HuangYi JinQingzhe KongZhongmin LeiXu WeiPrimary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase the risk of fracture. We conducted the systematic review to evaluate the effects of moxibustion for POP in randomized controlled trials (RCTs).Eight databases were searched from their inception to July 30, 2016. The RCTs reporting the moxibustion as a monotherapy or in combination with conventional therapy for POP were enrolled. The outcomes might be fracture incidence, quality of life, clinical symptoms, death attributed to osteoporosis, adverse effect, bone mineral density (BMD), and biochemical indicators. Literature selection, data abstraction, quality evaluation, and data analysis were in accordance with Cochrane standards.Thirteen trials including 808 patients were included. Meta-analysis was not conducted because of the obvious clinical or statistical heterogeneity. Limited evidence suggested that moxibustion plus anti-osteoporosis medicine might be more effective in relieving the pain (visual analogue scale scores average changed 2 scores between groups, 4 trials), increasing the BMD of femoral neck (average changed 0.4 g/cm2 between groups, 3 trials), and improving the level of bone gla protein, osteoprotegerin and bone alkaline phosphatase (2 trials) compared with anti-osteoporosis medicine alone. However, the quality of previous studies was evaluated as generally poor. The safety evidence of moxibustion was still insufficient. Due to the paucity of high-quality studies, there was no definite conclusion about the efficacy and safety of moxibustion treating POP although parts of positive results were presented. Future research should pay attention to the dose-response relation and fracture incidence of moxibustion for POP.https://doi.org/10.1371/journal.pone.0178688 |
| spellingShingle | Fanping Xu Minghua Huang Yi Jin Qingzhe Kong Zhongmin Lei Xu Wei Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials. PLoS ONE |
| title | Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials. |
| title_full | Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials. |
| title_fullStr | Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials. |
| title_full_unstemmed | Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials. |
| title_short | Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials. |
| title_sort | moxibustion treatment for primary osteoporosis a systematic review of randomized controlled trials |
| url | https://doi.org/10.1371/journal.pone.0178688 |
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