Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery
As an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities. It offers unparalleled control over heating areas and temperatures, boasts high efficiency, an...
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25003263 |
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| author | Yu Chen Haifu Sun Yonggang Li Xixi Han Yuqing Yang Zheng Chen Xuequan Zhao Yuchen Qian Xishui Liu Feng Zhou Jiaxiang Bai Yusen Qiao |
| author_facet | Yu Chen Haifu Sun Yonggang Li Xixi Han Yuqing Yang Zheng Chen Xuequan Zhao Yuchen Qian Xishui Liu Feng Zhou Jiaxiang Bai Yusen Qiao |
| author_sort | Yu Chen |
| collection | DOAJ |
| description | As an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities. It offers unparalleled control over heating areas and temperatures, boasts high efficiency, and results in excellent tissue penetration, while remaining independent of biological tissues. With vast potential in biomedical applications ranging from antitumor therapy to thrombus dissolution, MHT harnesses magnetic nanoparticles (MNPs) to convert magnetic energy into thermal energy under an alternating magnetic field (AMF), thereby achieving therapeutic effects. Advanced magnetic nanocomposite platforms based on magnetic nanoparticles can avoid various risks associated with traditional tools, achieving precise, on-demand, or continuous targeted drug delivery and release through multiple approaches. The potential clinical applications of magnetic hyperthermia therapy are being progressively developed. The present article presents an exhaustive review of the research progress in magnetic hyperthermia therapy. Initially, the overall landscape of MHT was outlined, including physical heat generation mechanisms, types of magnetic nanoparticles and conductive nonmagnetic materials, strategies to increase the thermal efficiency of MNPs, and experimental evidence and research progress on “hot-spot” effects. This review has focused on biomedical applications and targeted drug delivery of innovative combination therapy strategies based on MHT. The progress of clinical trials on MNPs-mediated MHT (MNPs-MHT) is summarized below. Furthermore, the limitations, major challenges and prospects in the clinical translation of MHT are discussed. The objective of this work is to provide a panoramic view of biomedical applications and targeted drug delivery of MHT, which can potentially guide researchers and facilitate the successful implementation of advanced MNPs-MHT systems in the future. |
| format | Article |
| id | doaj-art-2cf17450240e48b283a00b4a4e3a50f7 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-2cf17450240e48b283a00b4a4e3a50f72025-08-20T03:34:29ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-11-015359162910.1016/j.bioactmat.2025.07.033Magnetic nanomaterials for hyperthermia-based therapy and controlled drug deliveryYu Chen0Haifu Sun1Yonggang Li2Xixi Han3Yuqing Yang4Zheng Chen5Xuequan Zhao6Yuchen Qian7Xishui Liu8Feng Zhou9Jiaxiang Bai10Yusen Qiao11Department of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaSchool of Clinical Medicine, Capital Medical University, Beijing, 100069, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Breast Surgery, Changhai Hospital, Naval Medical University, 800 Xiangyin Road, Shanghai, 200433, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China; Corresponding author.Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaAs an innovative physiotherapeutic approach, magnetic hyperthermia therapy (MHT) has unique advantages including minimal invasiveness, precise temperature control, and deep tissue penetration capabilities. It offers unparalleled control over heating areas and temperatures, boasts high efficiency, and results in excellent tissue penetration, while remaining independent of biological tissues. With vast potential in biomedical applications ranging from antitumor therapy to thrombus dissolution, MHT harnesses magnetic nanoparticles (MNPs) to convert magnetic energy into thermal energy under an alternating magnetic field (AMF), thereby achieving therapeutic effects. Advanced magnetic nanocomposite platforms based on magnetic nanoparticles can avoid various risks associated with traditional tools, achieving precise, on-demand, or continuous targeted drug delivery and release through multiple approaches. The potential clinical applications of magnetic hyperthermia therapy are being progressively developed. The present article presents an exhaustive review of the research progress in magnetic hyperthermia therapy. Initially, the overall landscape of MHT was outlined, including physical heat generation mechanisms, types of magnetic nanoparticles and conductive nonmagnetic materials, strategies to increase the thermal efficiency of MNPs, and experimental evidence and research progress on “hot-spot” effects. This review has focused on biomedical applications and targeted drug delivery of innovative combination therapy strategies based on MHT. The progress of clinical trials on MNPs-mediated MHT (MNPs-MHT) is summarized below. Furthermore, the limitations, major challenges and prospects in the clinical translation of MHT are discussed. The objective of this work is to provide a panoramic view of biomedical applications and targeted drug delivery of MHT, which can potentially guide researchers and facilitate the successful implementation of advanced MNPs-MHT systems in the future.http://www.sciencedirect.com/science/article/pii/S2452199X25003263Magnetic hyperthermia therapyMagnetic nanoparticlesAlternating magnetic fieldBiomedical applicationsDrug deliveryClinical trials |
| spellingShingle | Yu Chen Haifu Sun Yonggang Li Xixi Han Yuqing Yang Zheng Chen Xuequan Zhao Yuchen Qian Xishui Liu Feng Zhou Jiaxiang Bai Yusen Qiao Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery Bioactive Materials Magnetic hyperthermia therapy Magnetic nanoparticles Alternating magnetic field Biomedical applications Drug delivery Clinical trials |
| title | Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery |
| title_full | Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery |
| title_fullStr | Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery |
| title_full_unstemmed | Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery |
| title_short | Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery |
| title_sort | magnetic nanomaterials for hyperthermia based therapy and controlled drug delivery |
| topic | Magnetic hyperthermia therapy Magnetic nanoparticles Alternating magnetic field Biomedical applications Drug delivery Clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25003263 |
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