Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder
Repetitive transcranial magnetic stimulation (rTMS) has gained regulatory approval as an adjunctive treatment for obsessive–compulsive disorder (OCD) in adults. However, its application in adolescents remains largely untested. This editorial examines the limited evidence available, focusing on choic...
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Cambridge University Press
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| Series: | BJPsych Bulletin |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056469425101381/type/journal_article |
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| author | Raphael J. Leo Brandon L. Mariotti |
| author_facet | Raphael J. Leo Brandon L. Mariotti |
| author_sort | Raphael J. Leo |
| collection | DOAJ |
| description | Repetitive transcranial magnetic stimulation (rTMS) has gained regulatory approval as an adjunctive treatment for obsessive–compulsive disorder (OCD) in adults. However, its application in adolescents remains largely untested. This editorial examines the limited evidence available, focusing on choice of target, stimulation depth and methodological variation. Ethical challenges surrounding the use of rTMS in vulnerable populations, including informed consent and the unknown long-term effects on neurodevelopment, are also discussed. Although rTMS holds promise for treatment-resistant adolescent OCD, a cautious and ethically rigorous approach is essential before wider clinical adoption can be considered. |
| format | Article |
| id | doaj-art-2cf073ca950a4645a53dc4d64f4b59ce |
| institution | Kabale University |
| issn | 2056-4694 2056-4708 |
| language | English |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Bulletin |
| spelling | doaj-art-2cf073ca950a4645a53dc4d64f4b59ce2025-08-22T11:16:03ZengCambridge University PressBJPsych Bulletin2056-46942056-47081310.1192/bjb.2025.10138Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorderRaphael J. Leo0https://orcid.org/0000-0003-1373-3230Brandon L. Mariotti1https://orcid.org/0000-0002-8647-7592Department of Psychiatry, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, NY, USADepartment of Psychiatry, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, NY, USARepetitive transcranial magnetic stimulation (rTMS) has gained regulatory approval as an adjunctive treatment for obsessive–compulsive disorder (OCD) in adults. However, its application in adolescents remains largely untested. This editorial examines the limited evidence available, focusing on choice of target, stimulation depth and methodological variation. Ethical challenges surrounding the use of rTMS in vulnerable populations, including informed consent and the unknown long-term effects on neurodevelopment, are also discussed. Although rTMS holds promise for treatment-resistant adolescent OCD, a cautious and ethically rigorous approach is essential before wider clinical adoption can be considered.https://www.cambridge.org/core/product/identifier/S2056469425101381/type/journal_articleObsessive–compulsive disorderadolescencerTMS |
| spellingShingle | Raphael J. Leo Brandon L. Mariotti Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder BJPsych Bulletin Obsessive–compulsive disorder adolescence rTMS |
| title | Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder |
| title_full | Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder |
| title_fullStr | Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder |
| title_full_unstemmed | Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder |
| title_short | Limited evidence and ethical considerations in rTMS trials for adolescents with obsessive–compulsive disorder |
| title_sort | limited evidence and ethical considerations in rtms trials for adolescents with obsessive compulsive disorder |
| topic | Obsessive–compulsive disorder adolescence rTMS |
| url | https://www.cambridge.org/core/product/identifier/S2056469425101381/type/journal_article |
| work_keys_str_mv | AT raphaeljleo limitedevidenceandethicalconsiderationsinrtmstrialsforadolescentswithobsessivecompulsivedisorder AT brandonlmariotti limitedevidenceandethicalconsiderationsinrtmstrialsforadolescentswithobsessivecompulsivedisorder |