Linking Innate and Adaptive Immunity: Human Vγ9Vδ2 T Cells Enhance CD40 Expression and HMGB-1 Secretion
γδ T cells play an important role in regulating the immune response to stress stimuli; however, the mean by which these innate lymphocytes fulfill this function remains poorly defined. The main subset of human peripheral blood γδ T cells responds to nonpeptidic antigens, such as isopentylpyrophospha...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/819408 |
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| Summary: | γδ T cells play an important role in regulating the immune response to stress stimuli; however, the mean by which these innate lymphocytes fulfill this function remains
poorly defined. The main subset of human peripheral blood γδ T cells responds to
nonpeptidic antigens, such as isopentylpyrophosphate (IPP), a metabolite in the
mevalonate pathway for both eukaryote and prokaryote cells. IPP-primed γδ T cells
significantly augment the inflammatory response mediated by monocytes and αβ T cells
to TSST-1, the staphylococcal superantigen that is the major causative agent of toxic
shock syndrome. Here we show that the small pool of activated peripheral γδ T cells
induces an early upregulation of CD40 on monocytes and the local release of High
Mobility Group Box-1 (HMGB-1), the molecule designated as the late mediator of
systemic inflammation. This finding provides a new basis for how γδ T cells may serve
as influential modulators of both endogenous and exogenous stress stimuli. |
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| ISSN: | 0962-9351 1466-1861 |