Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate
Cell-mediated immunity is considered to be normal in Darier's Disease (DD), an inherited skin disorder complicated by skin infections. To date, there are no investigations on the local inflammatory infiltrate in DD skin lesions. In this immunohistochemical study we characterized and quantified...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/350304 |
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| author | Clelia Miracco Francesco Pietronudo Vasileios Mourmouras Michele Pellegrino Monica Onorati Maria Grazia Mastrogiulio Luca Cantarini Pietro Luzi |
| author_facet | Clelia Miracco Francesco Pietronudo Vasileios Mourmouras Michele Pellegrino Monica Onorati Maria Grazia Mastrogiulio Luca Cantarini Pietro Luzi |
| author_sort | Clelia Miracco |
| collection | DOAJ |
| description | Cell-mediated immunity is considered to be normal in Darier's Disease (DD), an inherited skin disorder complicated by skin infections. To date, there are no investigations on the local inflammatory infiltrate in DD skin lesions. In this immunohistochemical study we characterized and quantified it, making comparisons with two other inflammatory skin disorders, that is, pemphigus vulgaris (PV) and lichen ruber planus (LRP), and with the normal skin (NSk). We found a significant (𝑃<.05) decrease of CD1a+ Langerhans cells (LCs) in DD, compared to PV, LRP, and NSk, and of CD123+ plasmacytoid dendritic cells (pDCs), compared to PV and LRP. We hypothesize that the genetic damage of keratinocytes might result in a loss of some subsets of dendritic cells and, consequently, in an impaired local immune response, which might worsen the infections that inevitably occur in this disease. |
| format | Article |
| id | doaj-art-2ceda436eccc4a90a34f7e781bd106d3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2ceda436eccc4a90a34f7e781bd106d32025-02-03T06:11:13ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/350304350304Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory InfiltrateClelia Miracco0Francesco Pietronudo1Vasileios Mourmouras2Michele Pellegrino3Monica Onorati4Maria Grazia Mastrogiulio5Luca Cantarini6Pietro Luzi7Section of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte, 6, 53100 Siena, ItalySection of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte, 6, 53100 Siena, ItalySection of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte, 6, 53100 Siena, ItalySection of Dermatology, Department of Clinical Medicine and Immunological Science, University of Siena, 53100 Siena, ItalySection of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte, 6, 53100 Siena, ItalySection of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte, 6, 53100 Siena, ItalyUnit of Rheumatology, Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, University of Siena, Policlinico Le Scotte, 53100 Siena, ItalyDepartment of Odontostomatological and Ophthalmological Science, University of Siena, 53100 Siena, ItalyCell-mediated immunity is considered to be normal in Darier's Disease (DD), an inherited skin disorder complicated by skin infections. To date, there are no investigations on the local inflammatory infiltrate in DD skin lesions. In this immunohistochemical study we characterized and quantified it, making comparisons with two other inflammatory skin disorders, that is, pemphigus vulgaris (PV) and lichen ruber planus (LRP), and with the normal skin (NSk). We found a significant (𝑃<.05) decrease of CD1a+ Langerhans cells (LCs) in DD, compared to PV, LRP, and NSk, and of CD123+ plasmacytoid dendritic cells (pDCs), compared to PV and LRP. We hypothesize that the genetic damage of keratinocytes might result in a loss of some subsets of dendritic cells and, consequently, in an impaired local immune response, which might worsen the infections that inevitably occur in this disease.http://dx.doi.org/10.1155/2010/350304 |
| spellingShingle | Clelia Miracco Francesco Pietronudo Vasileios Mourmouras Michele Pellegrino Monica Onorati Maria Grazia Mastrogiulio Luca Cantarini Pietro Luzi Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate Mediators of Inflammation |
| title | Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate |
| title_full | Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate |
| title_fullStr | Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate |
| title_full_unstemmed | Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate |
| title_short | Possible Implication of Local Immune Response in Darier's Disease: An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate |
| title_sort | possible implication of local immune response in darier s disease an immunohistochemical characterization of lesional inflammatory infiltrate |
| url | http://dx.doi.org/10.1155/2010/350304 |
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