Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma
Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/1792582 |
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| author | Osmond C. Wu Berje H. Shammassian Arunit J. S. Chugh Aparna Harbhajanka Manish K. Kasliwal |
| author_facet | Osmond C. Wu Berje H. Shammassian Arunit J. S. Chugh Aparna Harbhajanka Manish K. Kasliwal |
| author_sort | Osmond C. Wu |
| collection | DOAJ |
| description | Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of the spine outside the setting of neurofibromatosis is extremely rare and can masquerade as common benign nerve sheath tumors, on imaging. An older age at presentation with short duration of symptoms and prior regional radiation treatment encompassing the spine in the treatment field regardless of remoteness should alert the oncologists and neurosurgeons to the possible existence of this rare and aggressive tumor, as the management, and overall prognosis of this tumor is distinctly different compared to the usual intradural spinal tumors. |
| format | Article |
| id | doaj-art-2ced2d4dae314300883bd37f8912b302 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-2ced2d4dae314300883bd37f8912b3022025-02-03T01:05:17ZengWileyCase Reports in Neurological Medicine2090-66682090-66762020-01-01202010.1155/2020/17925821792582Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular SeminomaOsmond C. Wu0Berje H. Shammassian1Arunit J. S. Chugh2Aparna Harbhajanka3Manish K. Kasliwal4Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USADepartment of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USADepartment of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USADepartment of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USADepartment of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USAPrimary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. Intradural MPNSTs of the spine outside the setting of neurofibromatosis is extremely rare and can masquerade as common benign nerve sheath tumors, on imaging. An older age at presentation with short duration of symptoms and prior regional radiation treatment encompassing the spine in the treatment field regardless of remoteness should alert the oncologists and neurosurgeons to the possible existence of this rare and aggressive tumor, as the management, and overall prognosis of this tumor is distinctly different compared to the usual intradural spinal tumors.http://dx.doi.org/10.1155/2020/1792582 |
| spellingShingle | Osmond C. Wu Berje H. Shammassian Arunit J. S. Chugh Aparna Harbhajanka Manish K. Kasliwal Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma Case Reports in Neurological Medicine |
| title | Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma |
| title_full | Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma |
| title_fullStr | Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma |
| title_full_unstemmed | Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma |
| title_short | Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma |
| title_sort | ominous occurrence of spinal intradural primary malignant peripheral nerve sheath tumor four decades following radiation therapy for testicular seminoma |
| url | http://dx.doi.org/10.1155/2020/1792582 |
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