Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study

Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study

Abstract Background Glucokinase activator (GKA) has shown potential in influencing cardio-cerebrovascular diseases (CVDs), yet its metabolic mechanism remains unclear. Circulating metabolites play a significant role in the etiology of CVDs. We hypothesized that the effects of GKA on cardio-cerebrova...

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Bibliographic Details
Main Authors:	Xiaohan Wang, Weimeng Cheng, Tingting Xu, Ping He, Tianyue Li, Ying Zhang, Zhonghai Wei
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Cardiovascular Diabetology
Subjects:	Atrial fibrillation Cardio-cerebrovascular diseases Circulating metabolites Glucokinase activator Mendelian randomization Stroke
Online Access:	https://doi.org/10.1186/s12933-025-02851-0
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