Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation
Prion–like domains (PrLDs), a unique type of low–complexity domain (LCD) or intrinsically disordered region (IDR), have been shown to mediate protein liquid–liquid phase separation (LLPS). Recent research has increasingly focused on how prion–like proteins (PrLPs) regulate plant growth, development,...
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| Format: | Article |
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MDPI AG
2024-09-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/13/18/2666 |
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| author | Peisong Wu Yihao Li |
| author_facet | Peisong Wu Yihao Li |
| author_sort | Peisong Wu |
| collection | DOAJ |
| description | Prion–like domains (PrLDs), a unique type of low–complexity domain (LCD) or intrinsically disordered region (IDR), have been shown to mediate protein liquid–liquid phase separation (LLPS). Recent research has increasingly focused on how prion–like proteins (PrLPs) regulate plant growth, development, and stress responses. This review provides a comprehensive overview of plant PrLPs. We analyze the structural features of PrLPs and the mechanisms by which PrLPs undergo LLPS. Through gene ontology (GO) analysis, we highlight the diverse molecular functions of PrLPs and explore how PrLPs influence plant development and stress responses via phase separation. Finally, we address unresolved questions about PrLP regulatory mechanisms, offering prospects for future research. |
| format | Article |
| id | doaj-art-2ce938544d534492b8ae67b54df2aff1 |
| institution | OA Journals |
| issn | 2223-7747 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-2ce938544d534492b8ae67b54df2aff12025-08-20T01:55:48ZengMDPI AGPlants2223-77472024-09-011318266610.3390/plants13182666Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase SeparationPeisong Wu0Yihao Li1Faculty of Arts and Sciences, Beijing Normal University, Zhuhai 519087, ChinaFaculty of Arts and Sciences, Beijing Normal University, Zhuhai 519087, ChinaPrion–like domains (PrLDs), a unique type of low–complexity domain (LCD) or intrinsically disordered region (IDR), have been shown to mediate protein liquid–liquid phase separation (LLPS). Recent research has increasingly focused on how prion–like proteins (PrLPs) regulate plant growth, development, and stress responses. This review provides a comprehensive overview of plant PrLPs. We analyze the structural features of PrLPs and the mechanisms by which PrLPs undergo LLPS. Through gene ontology (GO) analysis, we highlight the diverse molecular functions of PrLPs and explore how PrLPs influence plant development and stress responses via phase separation. Finally, we address unresolved questions about PrLP regulatory mechanisms, offering prospects for future research.https://www.mdpi.com/2223-7747/13/18/2666prion–like proteinsliquid–liquid phase separationprion–like domainsplant developmentstress responses |
| spellingShingle | Peisong Wu Yihao Li Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation Plants prion–like proteins liquid–liquid phase separation prion–like domains plant development stress responses |
| title | Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation |
| title_full | Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation |
| title_fullStr | Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation |
| title_full_unstemmed | Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation |
| title_short | Prion–like Proteins in Plants: Key Regulators of Development and Environmental Adaptation via Phase Separation |
| title_sort | prion like proteins in plants key regulators of development and environmental adaptation via phase separation |
| topic | prion–like proteins liquid–liquid phase separation prion–like domains plant development stress responses |
| url | https://www.mdpi.com/2223-7747/13/18/2666 |
| work_keys_str_mv | AT peisongwu prionlikeproteinsinplantskeyregulatorsofdevelopmentandenvironmentaladaptationviaphaseseparation AT yihaoli prionlikeproteinsinplantskeyregulatorsofdevelopmentandenvironmentaladaptationviaphaseseparation |