Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases

Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases

Abstract High-grade glioma with pleomorphic and pseudopapillary features (HPAP) is a recently identified methylation cluster comprised of relatively circumscribed gliomas enriched for variants in TP53, RB1, NF1, NF2, BRAF and with a more favorable clinical outcome than IDH-wildtype glioblastoma. Her...

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Main Authors: Sabrina Rossi, Isabella Giovannoni, Sara Patrizi, Andrea Mafficcini, Eleonora Piccirilli, Giuseppe Kenneth Ricciardi, Giacomina Megaro, Francesca Arienzo, Chantal Tancredi, Emanuele Agolini, Andrea Carai, Angela Mastronuzzi, Caterina Giannini, Franco Locatelli, Rita Alaggio, Giovanna Stefania Colafati, Viola Alesi, Evelina Miele, Valeria Barresi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
High-grade glioma with pleomorphic and pseudopapillary features
Ependymoma
Astroblastoma MN1-altered
TP53 mutation
RB1 mutation
NF2 mutation
Online Access:https://doi.org/10.1186/s40478-025-02017-9
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