Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies
BackgroundAutism spectrum disorder is a distinctive developmental condition which is caused by an interaction between genetic vulnerability and environmental factors. Biomarkers play a crucial role in understanding disease characteristics for diagnosis, prognosis, and treatment. This study employs b...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1514678/full |
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| author | Fang Jin Zhidan Wang |
| author_facet | Fang Jin Zhidan Wang |
| author_sort | Fang Jin |
| collection | DOAJ |
| description | BackgroundAutism spectrum disorder is a distinctive developmental condition which is caused by an interaction between genetic vulnerability and environmental factors. Biomarkers play a crucial role in understanding disease characteristics for diagnosis, prognosis, and treatment. This study employs bibliometric analysis to identify and review the 100 top-cited articles’ characteristics, current research hotspots and future directions of autism biomarkers.MethodsA comprehensive search of autism biomarkers studies was retrieved from the Web of Science Core Collection database with a combined keyword search strategy. A comprehensive analysis of the top 100 articles was conducted with CiteSpace, VOSviewer, and Excel, including citations, countries, authors, and keywords.ResultsThe top 100 cited studies were published between 1988 and 2021, with the United States led in productivity. Core biomarkers such as genetics, children, oxidative stress, and mitochondrial dysfunction are well-established. Potential trends for future research may include brain studies, metabolomics, and associations with other psychiatric disorders.ConclusionThis pioneering bibliometric analysis provides a comprehensive compilation of the 100 most-cited studies on autism, which not only offers a valuable resource for doctors, and researchers but shedding insights into current shortcomings and future endeavors. Future research should prioritize the application of emerging technologies for biomarkers, longitudinal study of biomarkers, and specificity of autism biomarkers to advance the precision of ASD diagnosis and treatment. |
| format | Article |
| id | doaj-art-2ce32a9b2fc44366a7923d5cebd634df |
| institution | OA Journals |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-2ce32a9b2fc44366a7923d5cebd634df2025-08-20T02:38:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-12-011810.3389/fnins.2024.15146781514678Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studiesFang JinZhidan WangBackgroundAutism spectrum disorder is a distinctive developmental condition which is caused by an interaction between genetic vulnerability and environmental factors. Biomarkers play a crucial role in understanding disease characteristics for diagnosis, prognosis, and treatment. This study employs bibliometric analysis to identify and review the 100 top-cited articles’ characteristics, current research hotspots and future directions of autism biomarkers.MethodsA comprehensive search of autism biomarkers studies was retrieved from the Web of Science Core Collection database with a combined keyword search strategy. A comprehensive analysis of the top 100 articles was conducted with CiteSpace, VOSviewer, and Excel, including citations, countries, authors, and keywords.ResultsThe top 100 cited studies were published between 1988 and 2021, with the United States led in productivity. Core biomarkers such as genetics, children, oxidative stress, and mitochondrial dysfunction are well-established. Potential trends for future research may include brain studies, metabolomics, and associations with other psychiatric disorders.ConclusionThis pioneering bibliometric analysis provides a comprehensive compilation of the 100 most-cited studies on autism, which not only offers a valuable resource for doctors, and researchers but shedding insights into current shortcomings and future endeavors. Future research should prioritize the application of emerging technologies for biomarkers, longitudinal study of biomarkers, and specificity of autism biomarkers to advance the precision of ASD diagnosis and treatment.https://www.frontiersin.org/articles/10.3389/fnins.2024.1514678/fullautism biomarkersbibliometric analysisgeneticsbrainmetabolomicsoxidative stress |
| spellingShingle | Fang Jin Zhidan Wang Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies Frontiers in Neuroscience autism biomarkers bibliometric analysis genetics brain metabolomics oxidative stress |
| title | Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies |
| title_full | Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies |
| title_fullStr | Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies |
| title_full_unstemmed | Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies |
| title_short | Mapping the structure of biomarkers in autism spectrum disorder: a review of the most influential studies |
| title_sort | mapping the structure of biomarkers in autism spectrum disorder a review of the most influential studies |
| topic | autism biomarkers bibliometric analysis genetics brain metabolomics oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1514678/full |
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