The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma
Background/Aim. Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology. Methods. The study included 120 women with primary invasive ductal carcinoma of the breast. We correlated the...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2006-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500611921I.pdf |
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| author | Ivković-Kapicl Tatjana Knežević-Ušaj Slavica Panjković Milana Ninčić Dejan Mastilović Katarina |
| author_facet | Ivković-Kapicl Tatjana Knežević-Ušaj Slavica Panjković Milana Ninčić Dejan Mastilović Katarina |
| author_sort | Ivković-Kapicl Tatjana |
| collection | DOAJ |
| description | Background/Aim. Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology. Methods. The study included 120 women with primary invasive ductal carcinoma of the breast. We correlated the patients age and diagnosis with the commonly used clinical, pathological factors and newer tumor biomarkers. Immunohistochemical staining was conducted for p53, c-erbB-2, Ki-67, estrogen (ER), progesterone (PR) receptors, and angiogenesis. Results. In our study, the patients with axillary lymph node metastases and negative steroid hormone receptors (ER and PR) were significantly younger than the patients with nodal involvement and positive hormone receptors. There was also a significant association between the patients age, diagnosis and angiogenesis. No association was found between the patients age and tumor size, histological grade, p53, c-erbB-2, and Ki-67. Conclusion. The results of our study supported only partially the hypothesis that the breast cancer biology is significantly affected by a patient's age. |
| format | Article |
| id | doaj-art-2ce2f0d45b3e4782a733a47667d30df9 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2ce2f0d45b3e4782a733a47667d30df92025-08-20T02:24:18ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502006-01-01631192192710.2298/VSP0611921IThe influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinomaIvković-Kapicl TatjanaKnežević-Ušaj SlavicaPanjković MilanaNinčić DejanMastilović KatarinaBackground/Aim. Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology. Methods. The study included 120 women with primary invasive ductal carcinoma of the breast. We correlated the patients age and diagnosis with the commonly used clinical, pathological factors and newer tumor biomarkers. Immunohistochemical staining was conducted for p53, c-erbB-2, Ki-67, estrogen (ER), progesterone (PR) receptors, and angiogenesis. Results. In our study, the patients with axillary lymph node metastases and negative steroid hormone receptors (ER and PR) were significantly younger than the patients with nodal involvement and positive hormone receptors. There was also a significant association between the patients age, diagnosis and angiogenesis. No association was found between the patients age and tumor size, histological grade, p53, c-erbB-2, and Ki-67. Conclusion. The results of our study supported only partially the hypothesis that the breast cancer biology is significantly affected by a patient's age.http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500611921I.pdfbreastneoplasmsage groupsneoplasm staginghistologybiological markersreceptorsestrogenreceptorsprogesterone |
| spellingShingle | Ivković-Kapicl Tatjana Knežević-Ušaj Slavica Panjković Milana Ninčić Dejan Mastilović Katarina The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma Vojnosanitetski Pregled breast neoplasms age groups neoplasm staging histology biological markers receptors estrogen receptors progesterone |
| title | The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma |
| title_full | The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma |
| title_fullStr | The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma |
| title_full_unstemmed | The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma |
| title_short | The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma |
| title_sort | influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma |
| topic | breast neoplasms age groups neoplasm staging histology biological markers receptors estrogen receptors progesterone |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500611921I.pdf |
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