Combinatorial mutagenesis and fermentation optimization biotechnologies synergistically enhance monacolin K content in functional red yeast rice

Combinatorial mutagenesis and fermentation optimization biotechnologies synergistically enhance monacolin K content in functional red yeast rice

IntroductionRed yeast rice (RYR) is produced through solid-state fermentation by Monascus genus. Its functional component, Monacolin K (MK), has the same structure as lovastatin and can effectively inhibit HMG-CoA reductase, thereby reducing serum cholesterol.MethodsA combinatorial mutagenesis strat...

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Bibliographic Details
Main Authors: Zhengyan Wu, Chan Zhang, Qing Liu, Song Zhang, Qi Yang, Jun Liu, Dong Lu, Xiang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
Monascus purpureus
monacolin K
mutagenesis
solid-state fermentation
RT-qPCR
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1669985/full
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