Association between urinary mixture metal levels and olfactory function in coal miners
BackgroundExposure to occupational metallic mixtures has a potential impact on olfactory function. However, research evidence is limited on the potential impact of exposure to metallic mixtures and olfactory dysfunction. Furthermore, the coal dust generated contains multiple various metals during co...
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Frontiers Media S.A.
2024-09-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1447290/full |
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| author | Yang Li Yang Li Yuxuan Jiao Yuxuan Jiao Rong Hu Rong Hu Guilin Hu Guilin Hu Ge Shi Ge Shi Kaidong Wang Kaidong Wang Ai Qi Ai Qi Yujing Li Yujing Li Yonghang Li Yonghang Li Zhuoheng Shen Zhuoheng Shen Jiafei Yang Jiafei Yang Zhiyun Ha Zhiyun Ha Yaowen Yang Yaowen Yang Jiangping Li Jiangping Li Jiangping Li Min Huang Min Huang |
| author_facet | Yang Li Yang Li Yuxuan Jiao Yuxuan Jiao Rong Hu Rong Hu Guilin Hu Guilin Hu Ge Shi Ge Shi Kaidong Wang Kaidong Wang Ai Qi Ai Qi Yujing Li Yujing Li Yonghang Li Yonghang Li Zhuoheng Shen Zhuoheng Shen Jiafei Yang Jiafei Yang Zhiyun Ha Zhiyun Ha Yaowen Yang Yaowen Yang Jiangping Li Jiangping Li Jiangping Li Min Huang Min Huang |
| author_sort | Yang Li |
| collection | DOAJ |
| description | BackgroundExposure to occupational metallic mixtures has a potential impact on olfactory function. However, research evidence is limited on the potential impact of exposure to metallic mixtures and olfactory dysfunction. Furthermore, the coal dust generated contains multiple various metals during coal mining, and no study yet has focus on the olfactory dysfunction of coal miners.ObjectivesIn this study, we evaluate the association between urinary metallic mixtures and olfactory function in coal miners, while also exploring the potential applicability of plasma olfactory marker protein (OMP) as a biomarker for assessing olfaction.MethodsFrom July to October 2023, coal workers from seven different coal mining enterprises were recruited for the survey when they come for the employee health checkup. Ultimately, 376 participants were met the inclusion criteria and, respectively, determined with the concentrations of urine (16 metals) and plasma (OMP). Meanwhile, applying UPSIT to access their olfactory function. Binary logistic regression and restricted cubic spline (RCS) model were used to estimate the association of individual metals with olfactory function. Bayesian kernel machine regression (BKMR) and Quantile g-computation (QG-C) regression were employed to assess the overall association between metal mixtures and olfactory function and identify the major contributing elements.ResultsIn a single-metal model, two metals in urine were found to be significantly associated with olfactory function. RCS analysis further revealed that the association between Iron (Fe) and olfactory function was linear, while Lead (Pb) exhibited a non-linear. The BKMR model demonstrated a significant positive association between metal mixture concentration and olfactory function. Combined QG-C regression analysis suggested that metals Cr, Fe, Se, Sb, and Pb could impact the performance of the olfactory test (UPSIT), with Pb being identified as the most influential contributor. The correlation between plasma OMP protein levels and urinary metal concentrations was weak.ConclusionMultiple metals are associated with olfactory function in the coal miners. A significant positive association was observed between metal mixture concentrations and olfactory function, with Pb being the most important contributor. In this study, plasma OMP has not been demonstrated to serve as a biomarker for olfactory function. |
| format | Article |
| id | doaj-art-2ce0c9689f424e23b889db9867df890b |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-2ce0c9689f424e23b889db9867df890b2025-08-20T01:54:44ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-09-011210.3389/fpubh.2024.14472901447290Association between urinary mixture metal levels and olfactory function in coal minersYang Li0Yang Li1Yuxuan Jiao2Yuxuan Jiao3Rong Hu4Rong Hu5Guilin Hu6Guilin Hu7Ge Shi8Ge Shi9Kaidong Wang10Kaidong Wang11Ai Qi12Ai Qi13Yujing Li14Yujing Li15Yonghang Li16Yonghang Li17Zhuoheng Shen18Zhuoheng Shen19Jiafei Yang20Jiafei Yang21Zhiyun Ha22Zhiyun Ha23Yaowen Yang24Yaowen Yang25Jiangping Li26Jiangping Li27Jiangping Li28Min Huang29Min Huang30School of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaThe Fifth People’s Hospital of Ning Xia, Shizuishan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaThe Fifth People’s Hospital of Ning Xia, Shizuishan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan, ChinaSchool of Public Health, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, ChinaBackgroundExposure to occupational metallic mixtures has a potential impact on olfactory function. However, research evidence is limited on the potential impact of exposure to metallic mixtures and olfactory dysfunction. Furthermore, the coal dust generated contains multiple various metals during coal mining, and no study yet has focus on the olfactory dysfunction of coal miners.ObjectivesIn this study, we evaluate the association between urinary metallic mixtures and olfactory function in coal miners, while also exploring the potential applicability of plasma olfactory marker protein (OMP) as a biomarker for assessing olfaction.MethodsFrom July to October 2023, coal workers from seven different coal mining enterprises were recruited for the survey when they come for the employee health checkup. Ultimately, 376 participants were met the inclusion criteria and, respectively, determined with the concentrations of urine (16 metals) and plasma (OMP). Meanwhile, applying UPSIT to access their olfactory function. Binary logistic regression and restricted cubic spline (RCS) model were used to estimate the association of individual metals with olfactory function. Bayesian kernel machine regression (BKMR) and Quantile g-computation (QG-C) regression were employed to assess the overall association between metal mixtures and olfactory function and identify the major contributing elements.ResultsIn a single-metal model, two metals in urine were found to be significantly associated with olfactory function. RCS analysis further revealed that the association between Iron (Fe) and olfactory function was linear, while Lead (Pb) exhibited a non-linear. The BKMR model demonstrated a significant positive association between metal mixture concentration and olfactory function. Combined QG-C regression analysis suggested that metals Cr, Fe, Se, Sb, and Pb could impact the performance of the olfactory test (UPSIT), with Pb being identified as the most influential contributor. The correlation between plasma OMP protein levels and urinary metal concentrations was weak.ConclusionMultiple metals are associated with olfactory function in the coal miners. A significant positive association was observed between metal mixture concentrations and olfactory function, with Pb being the most important contributor. In this study, plasma OMP has not been demonstrated to serve as a biomarker for olfactory function.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1447290/fullMetal mixtureolfaction disorderscoal minersoccupational exposureUPSITBayesian kernel machine regression |
| spellingShingle | Yang Li Yang Li Yuxuan Jiao Yuxuan Jiao Rong Hu Rong Hu Guilin Hu Guilin Hu Ge Shi Ge Shi Kaidong Wang Kaidong Wang Ai Qi Ai Qi Yujing Li Yujing Li Yonghang Li Yonghang Li Zhuoheng Shen Zhuoheng Shen Jiafei Yang Jiafei Yang Zhiyun Ha Zhiyun Ha Yaowen Yang Yaowen Yang Jiangping Li Jiangping Li Jiangping Li Min Huang Min Huang Association between urinary mixture metal levels and olfactory function in coal miners Frontiers in Public Health Metal mixture olfaction disorders coal miners occupational exposure UPSIT Bayesian kernel machine regression |
| title | Association between urinary mixture metal levels and olfactory function in coal miners |
| title_full | Association between urinary mixture metal levels and olfactory function in coal miners |
| title_fullStr | Association between urinary mixture metal levels and olfactory function in coal miners |
| title_full_unstemmed | Association between urinary mixture metal levels and olfactory function in coal miners |
| title_short | Association between urinary mixture metal levels and olfactory function in coal miners |
| title_sort | association between urinary mixture metal levels and olfactory function in coal miners |
| topic | Metal mixture olfaction disorders coal miners occupational exposure UPSIT Bayesian kernel machine regression |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1447290/full |
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