Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases
<i>Helicobacter pylori</i> and <i>Candida</i> spp. are widespread microorganisms found in the human gastrointestinal tract, often coexisting in the same ecological niche. <i>H. pylori</i>, a Gram-negative bacterium, is a well-known pathogen responsible for gastrit...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/5/1172 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850127445178449920 |
|---|---|
| author | Joanna Braksator Anna Kofla-Dłubacz Katarzyna Antosz-Popiołek Hubert Szyller Joanna Koga-Batko Martyna Wrześniewska Maciej Dyda Tomasz Pytrus |
| author_facet | Joanna Braksator Anna Kofla-Dłubacz Katarzyna Antosz-Popiołek Hubert Szyller Joanna Koga-Batko Martyna Wrześniewska Maciej Dyda Tomasz Pytrus |
| author_sort | Joanna Braksator |
| collection | DOAJ |
| description | <i>Helicobacter pylori</i> and <i>Candida</i> spp. are widespread microorganisms found in the human gastrointestinal tract, often coexisting in the same ecological niche. <i>H. pylori</i>, a Gram-negative bacterium, is a well-known pathogen responsible for gastritis, peptic ulcers, and gastric cancer. In contrast, <i>Candida</i> fungi, often detected in food, particularly <i>Candida albicans</i>, are generally considered commensal organisms, but can become opportunistic pathogens under certain conditions. Recent studies suggest a possible link between these microorganisms, highlighting a new survival strategy of <i>H. pylori</i>, that is, its ability to internalize in <i>Candida</i> vacuoles. This phenomenon, confirmed by various microscopic and molecular techniques, may provide <i>H. pylori</i> with protection against adverse environmental conditions, especially clinically important antibiotic therapy. The basic premise of this theory is the ability of <i>H. pylori</i> to penetrate vacuoles in fungal cells, which then become a reservoir of infection, allowing the infection to recur. Understanding the interaction between <i>H. pylori</i> and <i>Candida</i> may offer new insights into the pathogenesis of gastrointestinal diseases and may lead to the development of treatments targeting both organisms simultaneously. The purpose of this article is to review the literature, considering the first observations on this problem in the literature and the current state of knowledge, and to suggest a direction for further research. |
| format | Article |
| id | doaj-art-2cddbb99d1ce458ea26e6d60fe9e1b6e |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-2cddbb99d1ce458ea26e6d60fe9e1b6e2025-08-20T02:33:40ZengMDPI AGBiomedicines2227-90592025-05-01135117210.3390/biomedicines13051172Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal DiseasesJoanna Braksator0Anna Kofla-Dłubacz1Katarzyna Antosz-Popiołek2Hubert Szyller3Joanna Koga-Batko4Martyna Wrześniewska5Maciej Dyda6Tomasz Pytrus72nd Clinical Department of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, Poland2nd Clinical Department of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Pediatric Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Pediatric Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Pediatric Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Pediatric Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, PolandStudent Scientific Group of Pediatric Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, Poland2nd Clinical Department of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, 50-369 Wroclaw, Poland<i>Helicobacter pylori</i> and <i>Candida</i> spp. are widespread microorganisms found in the human gastrointestinal tract, often coexisting in the same ecological niche. <i>H. pylori</i>, a Gram-negative bacterium, is a well-known pathogen responsible for gastritis, peptic ulcers, and gastric cancer. In contrast, <i>Candida</i> fungi, often detected in food, particularly <i>Candida albicans</i>, are generally considered commensal organisms, but can become opportunistic pathogens under certain conditions. Recent studies suggest a possible link between these microorganisms, highlighting a new survival strategy of <i>H. pylori</i>, that is, its ability to internalize in <i>Candida</i> vacuoles. This phenomenon, confirmed by various microscopic and molecular techniques, may provide <i>H. pylori</i> with protection against adverse environmental conditions, especially clinically important antibiotic therapy. The basic premise of this theory is the ability of <i>H. pylori</i> to penetrate vacuoles in fungal cells, which then become a reservoir of infection, allowing the infection to recur. Understanding the interaction between <i>H. pylori</i> and <i>Candida</i> may offer new insights into the pathogenesis of gastrointestinal diseases and may lead to the development of treatments targeting both organisms simultaneously. The purpose of this article is to review the literature, considering the first observations on this problem in the literature and the current state of knowledge, and to suggest a direction for further research.https://www.mdpi.com/2227-9059/13/5/1172<i>Helicobacter pylori</i>candidaeradicationmicrobial interactionsgastrointestinal microbiota |
| spellingShingle | Joanna Braksator Anna Kofla-Dłubacz Katarzyna Antosz-Popiołek Hubert Szyller Joanna Koga-Batko Martyna Wrześniewska Maciej Dyda Tomasz Pytrus Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases Biomedicines <i>Helicobacter pylori</i> candida eradication microbial interactions gastrointestinal microbiota |
| title | Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases |
| title_full | Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases |
| title_fullStr | Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases |
| title_full_unstemmed | Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases |
| title_short | Co-Occurrence of <i>Helicobacter pylori</i> and <i>Candida</i> spp. Infections in the Pathogenesis of Gastrointestinal Diseases |
| title_sort | co occurrence of i helicobacter pylori i and i candida i spp infections in the pathogenesis of gastrointestinal diseases |
| topic | <i>Helicobacter pylori</i> candida eradication microbial interactions gastrointestinal microbiota |
| url | https://www.mdpi.com/2227-9059/13/5/1172 |
| work_keys_str_mv | AT joannabraksator cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT annakofladłubacz cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT katarzynaantoszpopiołek cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT hubertszyller cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT joannakogabatko cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT martynawrzesniewska cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT maciejdyda cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases AT tomaszpytrus cooccurrenceofihelicobacterpyloriiandicandidaisppinfectionsinthepathogenesisofgastrointestinaldiseases |