Modulating NPC1L1 to Potentiate PARP Inhibitor-Induced Ferroptosis and Immune Response in Triple-Negative Breast Cancer

Modulating NPC1L1 to Potentiate PARP Inhibitor-Induced Ferroptosis and Immune Response in Triple-Negative Breast Cancer

<b>Background/Objectives:</b> Poly (ADP-ribose) polymerase (PARP) inhibitors have shown significant efficacy in treating BRCA-mutated cancers; however, a significant proportion of patients fail to respond. Emerging evidence highlights the role of PARP in lipid metabolism, suggest-ing its...

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Bibliographic Details
Main Authors: Ge Li, Yuxia Yuan, Xinhua Wu, Lixian Wu
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
PARP inhibitor
lipid metabolism
NPC1L1
AKT inhibitor
immune response
Online Access:https://www.mdpi.com/1999-4923/17/5/554
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