A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study
Background: Coronavirus disease-2019 (COVID-19) is both an infective and inflammatory disorder. The liver is the principal site for the orchestration of inflammatory cascade after entry of SARS-CoV2 in humans. The study of liver-related parameters has immense potential to understand the pathophysiol...
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Jaypee Brothers Medical Publisher
2024-12-01
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| Series: | Bengal Physician Journal |
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| Online Access: | https://www.apibpj.com/doi/BPJ/pdf/10.5005/jp-journals-10070-8055 |
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| author | Indranil Thakur Arabinda Chatterjee Rina Das Debalina Mukherjee Somnath Das |
| author_facet | Indranil Thakur Arabinda Chatterjee Rina Das Debalina Mukherjee Somnath Das |
| author_sort | Indranil Thakur |
| collection | DOAJ |
| description | Background: Coronavirus disease-2019 (COVID-19) is both an infective and inflammatory disorder. The liver is the principal site for the orchestration of inflammatory cascade after entry of SARS-CoV2 in humans. The study of liver-related parameters has immense potential to understand the pathophysiologic alteration and identify the therapeutic targets related to COVID-19 infection.
Method: A single-center, prospective, cross-sectional, and non-interventional study was conducted on the patients who were COVID-19 positive through RT-PCR test. Comparing and correlating the parameters of liver function test (LFT) between the disease severity group (severe vs non-severe) and also the in-hospital-outcome group (discharge and death) and the assessment of the strength of association (by calculating odds ratio [OR]) of individual LFT parameters for disease severity and in-hospital outcomes.
Results: Among the total number of patients 507 suitable patients were identified. Liver function tests at presentation were considered for the study. Individual parameters in LFT were compared and the strength of association was measured with disease severity and in-hospital outcomes. Disease severity was measured by CURB 65, q SOFA, and AIIMS/ICMR 2021 Clinical severity scores. In-hospital outcomes were defined as discharge or death.
We observed significant differences with respect to serum albumin level, SGOT, SGPT, and albumin globulin ratio between severe and non-severe groups of COVID-19-positive patients. Hypoalbuminemia followed by transaminitis were the commonest abnormalities.
Conclusion: Among the individual LFT parameters, hypoalbuminemia followed by transaminitis were the most frequent abnormalities. The altered liver functions were strongly associated with disease severity and outcomes. Hypoalbuminemia and high transaminase (SGOT and SGPT) levels had strong association with disease severity and outcomes. |
| format | Article |
| id | doaj-art-2cda2bae9a0d481abbc097443aca720b |
| institution | DOAJ |
| issn | 2582-1202 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Bengal Physician Journal |
| spelling | doaj-art-2cda2bae9a0d481abbc097443aca720b2025-08-20T03:06:08ZengJaypee Brothers Medical PublisherBengal Physician Journal2582-12022024-12-0111310110610.5005/jp-journals-10070-80553A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center StudyIndranil Thakur0https://orcid.org/0000-0003-4163-0167Arabinda Chatterjee1Rina Das2https://orcid.org/0000-0002-8407-0561Debalina Mukherjee3Somnath Das4https://orcid.org/0000-0002-7805-6114Department of Medicine, Diamond Harbour Government Medical College & Hospital, Harindanga, Newtown, Diamond Harbour, South 24 Parganas, West Bengal, IndiaDepartment of Forensic Medicine and Toxicology, Jhargram Government Medical College & Hospital, Jhargram, West Bengal, IndiaRina Das, Department of Forensic Medicine and Toxicology, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India, Phone: +91 9433344450Independent Researcher, Diamond Harbour Government Medical College & Hospital, Harindanga, West Bengal, IndiaDepartment of Forensic Medicine and Toxicology, Bankura Sammilani Medical College, Kolkata, West Bengal, IndiaBackground: Coronavirus disease-2019 (COVID-19) is both an infective and inflammatory disorder. The liver is the principal site for the orchestration of inflammatory cascade after entry of SARS-CoV2 in humans. The study of liver-related parameters has immense potential to understand the pathophysiologic alteration and identify the therapeutic targets related to COVID-19 infection. Method: A single-center, prospective, cross-sectional, and non-interventional study was conducted on the patients who were COVID-19 positive through RT-PCR test. Comparing and correlating the parameters of liver function test (LFT) between the disease severity group (severe vs non-severe) and also the in-hospital-outcome group (discharge and death) and the assessment of the strength of association (by calculating odds ratio [OR]) of individual LFT parameters for disease severity and in-hospital outcomes. Results: Among the total number of patients 507 suitable patients were identified. Liver function tests at presentation were considered for the study. Individual parameters in LFT were compared and the strength of association was measured with disease severity and in-hospital outcomes. Disease severity was measured by CURB 65, q SOFA, and AIIMS/ICMR 2021 Clinical severity scores. In-hospital outcomes were defined as discharge or death. We observed significant differences with respect to serum albumin level, SGOT, SGPT, and albumin globulin ratio between severe and non-severe groups of COVID-19-positive patients. Hypoalbuminemia followed by transaminitis were the commonest abnormalities. Conclusion: Among the individual LFT parameters, hypoalbuminemia followed by transaminitis were the most frequent abnormalities. The altered liver functions were strongly associated with disease severity and outcomes. Hypoalbuminemia and high transaminase (SGOT and SGPT) levels had strong association with disease severity and outcomes.https://www.apibpj.com/doi/BPJ/pdf/10.5005/jp-journals-10070-8055coronavirus disease-2019c-reactive protein-albumin ratioliver function testserum albuminseverity |
| spellingShingle | Indranil Thakur Arabinda Chatterjee Rina Das Debalina Mukherjee Somnath Das A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study Bengal Physician Journal coronavirus disease-2019 c-reactive protein-albumin ratio liver function test serum albumin severity |
| title | A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study |
| title_full | A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study |
| title_fullStr | A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study |
| title_full_unstemmed | A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study |
| title_short | A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study |
| title_sort | cross sectional assessment of initial liver function tests between severe and non severe covid 19 patients and its correlation with in hospital outcomes a rural based single center study |
| topic | coronavirus disease-2019 c-reactive protein-albumin ratio liver function test serum albumin severity |
| url | https://www.apibpj.com/doi/BPJ/pdf/10.5005/jp-journals-10070-8055 |
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