Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence

Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence

IntroductionCancer’s inherent heterogeneity, marked by diverse genetic and molecular alterations, presents significant challenges for developing effective treatments. One such alteration is the regulation of disulfidoptosis, a recently discovered programmed cell death pathway. RPN1, a key regulator...

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Bibliographic Details
Main Authors: Lexin Qin, Tingting Liang, Hailong Zhang, Xian Gong, Meidan Wei, Xiangrong Song, Yaoyu Hu, Xinyu Zhu, Wentao Hu, Jianxiang Li, Jin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
RPN1
disulfidoptosis
endoplasmic reticulum stress
cellular senescence
immune microenvironment
SP1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1512445/full
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