Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature
Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They can arise in almost every organ of the body although they are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare sit...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/728479 |
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| author | Nagesh T. Sirsath K. Govind Babu Umesh Das C. S. Premlatha |
| author_facet | Nagesh T. Sirsath K. Govind Babu Umesh Das C. S. Premlatha |
| author_sort | Nagesh T. Sirsath |
| collection | DOAJ |
| description | Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They can arise in almost every organ of the body although they are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare site for neuroendocrine carcinoma. In contrast to the other regions, neuroendocrine tumours of the sinuses have been reported to be recurrent and locally destructive. Very few cases of paranasal sinus neuroendocrine carcinoma have been reported till date. Difficulty in pathologic diagnosis and rarity of this malignancy have hindered the progress in understanding the clinical course and improving outcomes. We herein report a case of poorly differentiated neuroendocrine tumour of ethmoid and sphenoid sinus with invasion of orbit and intracranial extension. The patient had complete response at the end of chemoradiation and he was disease-free for 9 months duration after which he developed bone metastasis without regional recurrence. |
| format | Article |
| id | doaj-art-2cd784044e564f0ba2fce7c8e12437e2 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-2cd784044e564f0ba2fce7c8e12437e22025-08-20T02:38:52ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/728479728479Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the LiteratureNagesh T. Sirsath0K. Govind Babu1Umesh Das2C. S. Premlatha3Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, Karnataka, IndiaDepartment of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, Karnataka, IndiaDepartment of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, Karnataka, IndiaDepartment of Pathology, Kidwai Memorial Institute of Oncology, Bangalore 560029, Karnataka, IndiaNeuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They can arise in almost every organ of the body although they are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity and paranasal sinuses are a rare site for neuroendocrine carcinoma. In contrast to the other regions, neuroendocrine tumours of the sinuses have been reported to be recurrent and locally destructive. Very few cases of paranasal sinus neuroendocrine carcinoma have been reported till date. Difficulty in pathologic diagnosis and rarity of this malignancy have hindered the progress in understanding the clinical course and improving outcomes. We herein report a case of poorly differentiated neuroendocrine tumour of ethmoid and sphenoid sinus with invasion of orbit and intracranial extension. The patient had complete response at the end of chemoradiation and he was disease-free for 9 months duration after which he developed bone metastasis without regional recurrence.http://dx.doi.org/10.1155/2013/728479 |
| spellingShingle | Nagesh T. Sirsath K. Govind Babu Umesh Das C. S. Premlatha Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature |
| title_full | Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature |
| title_fullStr | Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature |
| title_full_unstemmed | Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature |
| title_short | Paranasal Sinus Neuroendocrine Carcinoma: A Case Report and Review of the Literature |
| title_sort | paranasal sinus neuroendocrine carcinoma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2013/728479 |
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